Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma

被引：7

作者：

Yang, Fan ^{[1
]}

Gao, Yuan ^{[1
]}

Chang, Yung-Ting ^{[1
]}

Zou, Yike ^{[2
]}

Houk, K. N. ^{[2
]}

Lu, Jing-Rong ^{[1
]}

He, Jing ^{[1
]}

Tang, Wei-Zhuo ^{[3
]}

Liao, Hong-Ze ^{[1
]}

Han, Hua ^{[4
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Res Ctr Marine Drugs,Dept Pharm, Sch Med,State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Changsha Univ, Coll Biol & Environm Engn, Changsha 410022, Peoples R China

[4] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 12期

基金：

中国国家自然科学基金;

关键词：

ANTINEOPLASTIC AGENTS; ISOAAPTAMINE; DERIVATIVES; PROGRESSION; PRODUCT;

D O I：

10.1021/acs.jnatprod.0c00769

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A chemical modification study was conducted on the marine natural product aaptamine (1), isolated from the marine sponge Aaptos aaptos. Thirty new derivatives substituted by various aromatic rings at the 3- and 7-positions of aaptamine were prepared by bromination, followed by the Suzuki coupling reaction. Sixteen compounds displayed cytotoxicities to four cancer cell lines (IC50 < 10 mu M). In particular, compound 5i demonstrated a significant antiproliferative effect on the extranodal natural killer/T-cell lymphoma (ENKT) cell line SNK-6 with an IC50 value of 0.6 mu M. Additionally, compound 5i showed cytotoxicities to multiple lymphoma cell lines, including Ramos, Raji, WSU-DLCL2, and SU-DHL-4 cells.

引用

页码：3758 / 3763

页数：6

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