Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands

被引：18

作者：

Li, Li-Jun ^{[1
]}

Yan, Qin-Qin ^{[1
]}

Liu, Guo-Jun ^{[1
]}

Yuan, Zhen ^{[1
]}

Lv, Zhen-Hua ^{[1
]}

Fu, Bin ^{[1
]}

Han, Yan-Jun ^{[1
]}

Du, Jian-Long ^{[1
]}

机构：

[1] Hebei Univ, Chem Biol Key Lab Hebei Prov, Baoding, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 06期

关键词：

platinum(II) complexes; reduced amino pyridine Schiff base; DNA interaction; antitumor activity; ANTIMICROBIAL ACTIVITY; TUMOR-CELLS; DNA; PALLADIUM(II); DRUGS; NUCLEOBASE; REDUCTION; ADDUCTS; GUANINE; SERIES;

D O I：

10.1080/09168451.2016.1259550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines.

引用

页码：1081 / 1089

页数：9

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