Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands

被引：18

作者：

Li, Li-Jun ^{[1
]}

Yan, Qin-Qin ^{[1
]}

Liu, Guo-Jun ^{[1
]}

Yuan, Zhen ^{[1
]}

Lv, Zhen-Hua ^{[1
]}

Fu, Bin ^{[1
]}

Han, Yan-Jun ^{[1
]}

Du, Jian-Long ^{[1
]}

机构：

[1] Hebei Univ, Chem Biol Key Lab Hebei Prov, Baoding, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 06期

关键词：

platinum(II) complexes; reduced amino pyridine Schiff base; DNA interaction; antitumor activity; ANTIMICROBIAL ACTIVITY; TUMOR-CELLS; DNA; PALLADIUM(II); DRUGS; NUCLEOBASE; REDUCTION; ADDUCTS; GUANINE; SERIES;

D O I：

10.1080/09168451.2016.1259550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines.

引用

页码：1081 / 1089

页数：9

共 50 条

[1] Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands
Li, Li-Jun
Fu, Bin
Qiao, Yu
Wang, Cheng
Huang, Ying-Ying
Liu, Chuan-Chuan
Tian, Chao
Du, Jian-Long
INORGANICA CHIMICA ACTA, 2014, 419 : 135 - 140
[2] Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes
Offiong, OE
Nfor, E
Ayi, AA
Martelli, S
TRANSITION METAL CHEMISTRY, 2000, 25 (04) : 369 - 373
[3] Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes
Offiong E. Offiong
Emmanuel Nfor
Ayi A. Ayi
Sante Martelli
Transition Metal Chemistry, 2000, 25 : 369 - 373
[4] Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases
Yan, Qin-Qin
Yuan, Zhen
Liu, Guo-Jun
Lv, Zheng-Hua
Fu, Bin
Du, Jian-Long
Li, Li-Jun
APPLIED ORGANOMETALLIC CHEMISTRY, 2017, 31 (06)
[5] Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with amino acid ligands in various coordination modes
Chaudhuri, Sangeeta Roy
Kaluderovic, Goran N.
Bette, Martin
Schmidt, Juergen
Schmidt, Harry
Paschke, Reinhard
Steinborn, Dirk
INORGANICA CHIMICA ACTA, 2013, 394 : 472 - 480
[6] Synthesis, characterization of platinum(II) complexes of Schiff base ligands and evaluation of cytotoxic activity of platinum nanoparticles
Gupta, Bhavana
Kumari, Anita
Belwal, Savita
Singh, R., V
Fahmi, Nighat
INORGANIC AND NANO-METAL CHEMISTRY, 2020, 50 (10) : 914 - 925
[7] Studies on synthesis, characterization, DNA interaction and cytotoxicity of ruthenium(II) Schiff base complexes
Raja, Gunasekaran
Butcher, Ray. J.
Jayabalakrishnan, Chinnasamy
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 94 : 210 - 215
[8] Synthesis and Characterization of Schiff Base Ligands and Their Palladium(II) Complexes
El-Qisairi, Arab K.
Qaseer, Hanan A.
Al-Btoush, Wa'el
JORDAN JOURNAL OF CHEMISTRY, 2023, 18 (01) : 43 - 52
[9] Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies
Yu, Hui
Zhang, Wei
Yu, Qing
Huang, Fu-Ping
Bian, He-Dong
Liang, Hong
MOLECULES, 2017, 22 (10):
[10] A new family of Ru(II) complexes with a tridentate pyridine Schiff-base ligand and bidentate co-ligands: synthesis, characterization, structure and in vitro cytotoxicity studies
Garza-Ortiz, Ariadna
Maheswari, Palanisamy Uma
Siegler, Maxime
Spek, Anthony L.
Reedijk, Jan
NEW JOURNAL OF CHEMISTRY, 2013, 37 (11) : 3450 - 3460

← 1 2 3 4 5 →