Gamete Formation Resets the Aging Clock in Yeast

被引：13
|
作者：
Unal, E. [1 ]
Amon, A. [1 ]
机构：
[1] MIT, Howard Hughes Med Inst, David H Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA
来源：
METABOLISM AND DISEASE | 2011年 / 76卷
基金：
美国国家卫生研究院;
关键词：
LIFE-SPAN; TELOMERE LENGTH; PROTEIN-DEGRADATION; RDNA; H4; SPORULATION; NUCLEOLUS; COMPLEXES; AGE; PHOSPHORYLATION;
D O I：
10.1101/sqb.2011.76.011379
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
引用
收藏
页码：73 / 80
页数：8
相关论文
共 50 条
  • [21] Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice
    Abe, Hiroshi
    Honma, Sato
    Honma, Ken-ichi
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (01) : R607 - R615
  • [22] THE BIOLOGIC AGING CLOCK
    KENT, S
    GERIATRICS, 1982, 37 (07) : 95 - &
  • [23] Importance of the Aging Male Gamete on ART Outcome
    Xie, P.
    Cheung, S.
    Rosenwaks, Z.
    Palermo, G.
    HUMAN REPRODUCTION, 2017, 32 : 435 - 436
  • [24] A THOROUGH GENETIC ASSESSMENT ON THE AGING MALE GAMETE
    Cheung, S.
    Rosenwaks, Z.
    Palermo, G. D.
    FERTILITY AND STERILITY, 2017, 108 (03) : E125 - E125
  • [25] Aging of the Suprachiasmatic Clock
    Farajnia, Sahar
    Deboer, Tom
    Rohling, Jos H. T.
    Meijer, Johanna H.
    Michel, Stephan
    NEUROSCIENTIST, 2014, 20 (01): : 44 - 55
  • [26] AGING AND CIRCADIAN CLOCK
    Hurley, Jennifer
    INNOVATION IN AGING, 2023, 7 : 510 - 511
  • [27] Melanopsin Resets Circadian Rhythms In Cells By Inducing Clock Gene Period1
    Yamashita, Shuhei
    Uehara, Tomoe
    Matsuo, Minako
    Kikuchi, Yo
    Numano, Rika
    IRAGO CONFERENCE 2013, 2014, 1585 : 40 - 44
  • [28] Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior
    Jeff R Jones
    Michael C Tackenberg
    Douglas G McMahon
    Nature Neuroscience, 2015, 18 : 373 - 375
  • [29] Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur
    Okubo, Naoki
    Fujiwara, Hiroyoshi
    Minami, Yoichi
    Kunimoto, Tatsuya
    Hosokawa, Toshihiro
    Emura, Yasuhiro Um
    Inokawa, Hitoshi
    Asada, Maki
    Oda, Ryo
    Kubo, Toshikazu
    Yagita, Kazuhiro
    ACTA ORTHOPAEDICA, 2015, 86 (05) : 627 - 631
  • [30] JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS
    Koh, Kyunghee
    Zheng, Xiangzhong
    Sehgal, Amita
    SCIENCE, 2006, 312 (5781) : 1809 - 1812
12345