Gamete Formation Resets the Aging Clock in Yeast

被引：13
|
作者：
Unal, E. [1 ]
Amon, A. [1 ]
机构：
[1] MIT, Howard Hughes Med Inst, David H Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA
来源：
METABOLISM AND DISEASE | 2011年 / 76卷
基金：
美国国家卫生研究院;
关键词：
LIFE-SPAN; TELOMERE LENGTH; PROTEIN-DEGRADATION; RDNA; H4; SPORULATION; NUCLEOLUS; COMPLEXES; AGE; PHOSPHORYLATION;
D O I：
10.1101/sqb.2011.76.011379
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
引用
收藏
页码：73 / 80
页数：8
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