Genetically engineered mesenchymal stem cells: applications in spine therapy

被引:11
|
作者
Aslan, Hadi [1 ]
Sheyn, Dima [1 ]
Gazit, Dan [1 ,2 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Ctr, Skeletal Biotech Lab, IL-91120 Jerusalem, Israel
[2] Cedars Sinai Med Ctr, Dept Surg, Stem Cell Therapeut Res Lab, Los Angeles, CA 90048 USA
关键词
back pain; bone morphogenetic proteins; gene therapy; intervertebral disc; mesenchymal stem cells; spinal fusion; BONE MORPHOGENETIC PROTEIN-2; ADENOVIRAL GENE-THERAPY; HUMAN ADIPOSE-TISSUE; LUMBAR-SPINE; IN-VIVO; FUSION MODEL; INTERVERTEBRAL DISC; INTERBODY FUSION; GROWTH-FACTOR; MARROW-CELLS;
D O I
10.2217/17460751.4.1.99
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Spine disorders and intervertebral disc degeneration are considered the main causes for the clinical condition commonly known as back pain. Spinal fusion by implanting autologous bone to produce bony bridging between the two vertebrae flanking the degenerated-intervertebral disc is currently the most efficient treatment for relieving the symptoms of back pain. However, donor-site morbidity, complications and the long healing time limit the success of this approach. Novel developments undertaken by regenerative medicine might bring more efficient and available treatments. Here We discuss the pros and cons of utilizing genetically engineered mesenchymal stem cells for inducing spinal fusion. The combination of the stem cells, gene and carrier are crucial elements for achieving optimal spinal fusion in both small and large animal models, which hopefully will lead to the development of clinical applications.
引用
收藏
页码:99 / 108
页数:10
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