Epigenetic Regulation of HIV-1 Latency in Astrocytes

被引：71

作者：

Narasipura, Srinivas D. ^{[1
]}

Kim, Stephanie ^{[1
]}

Al-Harthi, Lena ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 05期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; HISTONE DEACETYLASE INHIBITORS; NECROSIS-FACTOR-ALPHA; FETAL GLIAL-CELLS; INFECTED INDIVIDUALS; GAMMA-INTERFERON; GENE-EXPRESSION; PLASMA VIREMIA;

D O I：

10.1128/JVI.03333-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes. We have shown that class I histone deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significant role in silencing of HIV transcription in astrocytes. Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV.

引用

页码：3031 / 3038

页数：8

共 50 条

[21] Viral latency of HIV-1
Bouchat, Sophie
Van Lint, Carine
VIROLOGIE, 2019, 23 (04) : 195 - 210
[22] HIV-1 Latency Preface
Silvestri, Guido
Lichterfeld, Mathias
HIV-1 LATENCY, 2018, 417 : V - VI
[23] MECHANISMS OF HIV-1 LATENCY
BEDNARIK, DP
FOLKS, TM
AIDS, 1992, 6 (01) : 3 - 16
[24] Role of UHRF1 in transcriptional regulation and maintenance of HIV-1 latency
Victoriano, A. F. B.
Hibi, Y.
Gana, N. Tan
Asamitsu, K.
Okamoto, T.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2012, 15 : 15 - 15
[25] EVIDENCE FOR NEGATIVE REGULATION OF HIV EXPRESSION IN HUMAN ASTROCYTES PERSISTENTLY INFECTED WITH HIV-1
BRACKWERNER, R
KLEINSCHMIDT, A
LUDVIGSEN, A
NEUMANN, M
ERFLE, V
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (05) : 928 - 928
[26] RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency
Catalina Méndez
Scott Ledger
Kathy Petoumenos
Chantelle Ahlenstiel
Anthony D. Kelleher
Retrovirology, 15
[27] Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
Ishak D. Irwan
Hal P. Bogerd
Bryan R. Cullen
Nature Microbiology, 2022, 7 : 2101 - 2113
[28] Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
Irwan, Ishak D.
Bogerd, Hal P.
Cullen, Bryan R.
NATURE MICROBIOLOGY, 2022, 7 (12) : 2101 - +
[29] The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter
Chao, Ti-Chun
Zhang, Qiong
Li, Zhonghan
Tiwari, Shashi Kant
Qin, Yue
Yau, Edwin
Sanchez, Ana
Singh, Gatikrushna
Chang, Kungyen
Kaul, Marcus
Karris, Maile Ann Young
Rana, Tariq M.
MBIO, 2019, 10 (05):
[30] RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency
Mendez, Catalina
Ledger, Scott
Petoumenos, Kathy
Ahlenstiel, Chantelle
Kelleher, Anthony D.
RETROVIROLOGY, 2018, 15

← 1 2 3 4 5 →