Medicinal attributes of pyridine scaffold as anticancer targeting agents

被引：58
|
作者：
Mohamed, Esraa Ali [1 ]
Ismail, Nasser S. M. [2 ]
Hagras, Mohamed [3 ]
Refaat, Hanan [1 ]
机构：
[1] Future Univ Egypt, Fac Pharmaceut Sci & Pharmaceut Ind, Dept Pharmaceut Chem, Cairo, Egypt
[2] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
[3] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
来源：
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES | 2021年 / 7卷 / 01期
关键词：
Pyridines; Anticancer; Cytotoxic action; Tyrosine kinases; NF-KAPPA-B; BIOLOGICAL EVALUATION; DERIVATIVES; DESIGN; CANCER; ANGIOGENESIS; INHIBITORS; CDK9; EGFR;
D O I：
10.1186/s43094-020-00165-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text: Pyridine-containing compounds have increasing importance for medicinal application as antiviral, anticholinesterase activities, antimalarial, antimicrobial, antidiabetic and anticancer. This has generated concern among researchers in synthesising a variety of pyridine derivatives. Conclusion: This review focuses on different pyridine targets as anticancer and their pharmacophoric elements controlling its activity.
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收藏
页数：17
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