Acridine derivatives as chemotherapeutic agents

被引：1
|
作者：
Denny, WA [1 ]
机构：
[1] Univ Auckland, Fac Med & Hlth Sci, Auckland Canc Soc Res Ctr, Auckland 1, New Zealand
来源：
CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 18期
关键词：
acridine; amsacrine; antibacterial; anticancer; antimalarial; antiprotozoal; bis(acridine); DACA; nitracrine; pyrazoloacridine;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.
引用
收藏
页码：1655 / 1665
页数：11
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