Extracellular Matrix-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues

被引:33
|
作者
Bracaglia, Laura G. [1 ]
Fisher, John P. [1 ]
机构
[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA
基金
美国国家卫生研究院;
关键词
BOVINE PERICARDIUM; NANOFIBROUS SCAFFOLDS; ENDOTHELIAL-CELLS; BIOMATERIAL; DIFFERENTIATION; HYDROGELS; COLLAGEN; PROLIFERATION; TECHNOLOGY; SUBMUCOSA;
D O I
10.1002/adhm.201500236
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
An ideal tissue engineering scaffold should not only promote, but take an active role in, constructive remodeling and formation of site appropriate tissue. Extracellular matrix (ECM)-derived proteins provide unmatched cellular recognition, and therefore influence cellular response towards predicted remodeling behaviors. Materials built with only these proteins, however, can degrade rapidly or begin too weak to substitute for compliant, matrix-dense tissues. The focus of this Progress Report is on biohybrid materials that incorporate polymer components with ECM-derived proteins, to produce a substrate with desired mechanical and degradation properties, as well as actively guide tissue remodeling. Materials are described through four fabrication methods: 1) polymer and ECM-protein fibers woven together, 2) polymer and ECM proteins combined in a bilayer, 3) cell-built ECM on polymer scaffold, and 4) ECM proteins and polymers combined in a single hydrogel. Scaffolds from each fabrication method can achieve characteristics suitable for different types of tissue. In vivo testing has shown progressive remodeling in injury models, and suggests ECM-based biohybrid materials promote a prohealing immune response over single component alternatives. The prohealing immune response is associated with lasting success and long term host maintenance of the implant.
引用
收藏
页码:2475 / 2487
页数:13
相关论文
共 50 条
  • [21] Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials
    Shen, Wen
    Karumbaiah, Lohitash
    Liu, Xi
    Saxena, Tarun
    Chen, Shuodan
    Patkar, Radhika
    Bellamkonda, Ravi V.
    Allen, Mark G.
    MICROSYSTEMS & NANOENGINEERING, 2015, 1
  • [22] Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials
    Wen Shen
    Lohitash Karumbaiah
    Xi Liu
    Tarun Saxena
    Shuodan Chen
    Radhika Patkar
    Ravi V. Bellamkonda
    Mark G. Allen
    Microsystems & Nanoengineering, 1
  • [23] Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations
    Jo, Yeonggwon
    Hwang, Seung Hyeon
    Jang, Jinah
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (17)
  • [24] Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments
    Kim, Byoung Soo
    Das, Sanskrita
    Jang, Jinah
    Cho, Dong-Woo
    CHEMICAL REVIEWS, 2020, 120 (19) : 10941 - 10994
  • [25] Incremental Matrix-Based Subspace Method for Matrix-Based Feature Extraction
    Zhang, Zhaoyang
    Sun, Shijie
    Wang, Wei
    COMPLEXITY, 2020, 2020 (2020)
  • [26] Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior
    Cramer, Madeline C.
    Badylak, Stephen F.
    ANNALS OF BIOMEDICAL ENGINEERING, 2020, 48 (07) : 2132 - 2153
  • [27] Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction
    Farzamfar, Saeed
    Elia, Elissa
    Richer, Megan
    Chabaud, Stephane
    Naji, Mohammad
    Bolduc, Stephane
    BIOENGINEERING-BASEL, 2023, 10 (07):
  • [28] Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration
    Gunal, Gulcin
    Gokcen, Dincer
    Aydin, Halil Murat
    ACS APPLIED BIO MATERIALS, 2023, 6 (10) : 4100 - 4104
  • [29] Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing
    Lin-Cui Da
    Yi-Zhou Huang
    Hui-Qi Xie
    Bei-Hong Zheng
    Yong-Can Huang
    Sheng-Rong Du
    PHARMACEUTICS, 2021, 13 (11)
  • [30]  Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior
    Madeline C. Cramer
    Stephen F. Badylak
    Annals of Biomedical Engineering, 2020, 48 : 2132 - 2153