Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

被引：157

作者：

Natsuaki, Yohei ^{[1
,2
]}

Egawa, Gyohei ^{[1
]}

Nakamizo, Satoshi ^{[1
]}

Ono, Sachiko ^{[1
]}

Hanakawa, Sho ^{[1
]}

Okada, Takaharu ^{[3
]}

Kusuba, Nobuhiro ^{[1
]}

Otsuka, Atsushi ^{[1
]}

Kitoh, Akihiko ^{[1
]}

Honda, Tetsuya ^{[1
]}

Nakajima, Saeko ^{[1
]}

Tsuchiya, Soken ^{[4
]}

Sugimoto, Yukihiko ^{[4
]}

Ishii, Ken J. ^{[5
,6
]}

Tsutsui, Hiroko ^{[7
]}

Yagita, Hideo ^{[8
]}

Iwakura, Yoichiro ^{[9
,10
]}

Kubo, Masato ^{[11
,12
]}

Ng, Lai Guan ^{[13
]}

Hashimoto, Takashi ^{[2
]}

Fuentes, Judilyn ^{[14
]}

Guttman-Yassky, Emma ^{[14
]}

Miyachi, Yoshiki ^{[1
]}

Kabashima, Kenji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[2] Kurume Univ, Sch Med, Dept Dermatol, Fukuoka, Japan

[3] RIKEN Res Ctr Allergy & Immunol, Res Unit Immunodynam, Yokohama, Kanagawa, Japan

[4] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut Biochem, Kumamoto, Japan

[5] Natl Inst Biomed Innovat, Lab Adjuvant Innovat, Osaka, Japan

[6] Osaka Univ, Lab Vaccine Sci, WPI Immunol Frontier Res Ctr, Osaka, Japan

[7] Hyogo Coll Med, Dept Microbiol, Nishinomiya, Hyogo, Japan

[8] Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan

[9] Tokyo Univ Sci, Res Inst Biomed Sci, Chiba, Japan

[10] Chiba Univ, Med Mycol Res Ctr, Chiba, Japan

[11] RIKEN Ctr Integrat Med Sci, Lab Cytokine Regulat, Yokohama, Kanagawa, Japan

[12] Tokyo Univ Sci, Res Inst Biomed Sci, Div Mol Pathol, Chiba, Japan

[13] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore, Singapore

[14] Mt Sinai Sch Med Ctr, Icahn Sch Med, Dept Dermatol, New York, NY USA

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 11期

关键词：

CONTACT HYPERSENSITIVITY RESPONSE; RECEPTOR ANTAGONIST; ELICITATION PHASE; LYMPHOID-TISSUE; IMMUNE EVENTS; INTERLEUKIN-1; DERMATITIS; INDUCTION; ALLERGY; NODES;

D O I：

10.1038/ni.2992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1 alpha (IL-1 alpha) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity.

引用

页码：1064 / 1069

页数：6

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