Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

被引：37
|
作者：
Christensen, Alexander Sidelmann [1 ]
Moller, Jonas Bech [2 ]
Hasselbalch, Hans Carl [1 ]
机构：
[1] Univ Copenhagen, Roskilde Hosp, Dept Hematol, Roskilde, Denmark
[2] Novo Nordisk AS, Quantitat Clin Pharmacol, Soborg, Denmark
来源：
LEUKEMIA RESEARCH | 2014年 / 38卷 / 04期
关键词：
Myeloproliferative neoplasms; Essential thrombocythemia; Polycythemia vera; Myelofibrosis; Chronic kidney disease; Chronic inflammation; Hydroxyurea; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; CHRONIC INFLAMMATION; PREVALENCE; THROMBOSIS; DISORDERS; CYTOKINES; MORTALITY; SCLEROSIS;
D O I：
10.1016/j.leukres.2014.01.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. Methods: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. Results: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3 mL/min/1.73 m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts. Conclusion: Kidney impairment might contribute to the increased mortality observed in MPN patients. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：490 / 495
页数：6
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