Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

被引：23
|
作者：
Mohamed, M. S. [1 ]
Youns, M. M. [2 ]
Ahmed, N. M. [1 ]
机构：
[1] Helwan Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Cairo 11795, Egypt
[2] Helwan Univ, Fac Pharm, Dept Biochem, Cairo 11795, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 69卷
关键词：
Synthesis; 6-Aryl-5-cyano thiouracils; Antibacterial; Antifungal; Antioxidant activity; Radical scavenging; PYRIMIDINE-DERIVATIVES; ANTIBACTERIAL; INHIBITORS; ANTITUMOR; AGENTS;
D O I：
10.1016/j.ejmech.2013.08.032
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to ha-c) was synthesized from 6-ary1-4hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles (la-c).The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). All compounds were screened for their in-vitro antibacterial and antifungal activities. Compounds 7a, 7g and 9a-c showed pronounced antimicrobial activity than standards. Some of the newly synthesized compounds were evaluated for antioxidant activity. Compounds lc, 5c and 8c displayed promising free radical scavenging activity and found to be more potent than standard, ascorbic acid (vitamin C). (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：591 / 600
页数：10
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