Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

被引：23
|
作者：
Mohamed, M. S. [1 ]
Youns, M. M. [2 ]
Ahmed, N. M. [1 ]
机构：
[1] Helwan Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Cairo 11795, Egypt
[2] Helwan Univ, Fac Pharm, Dept Biochem, Cairo 11795, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 69卷
关键词：
Synthesis; 6-Aryl-5-cyano thiouracils; Antibacterial; Antifungal; Antioxidant activity; Radical scavenging; PYRIMIDINE-DERIVATIVES; ANTIBACTERIAL; INHIBITORS; ANTITUMOR; AGENTS;
D O I：
10.1016/j.ejmech.2013.08.032
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to ha-c) was synthesized from 6-ary1-4hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles (la-c).The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). All compounds were screened for their in-vitro antibacterial and antifungal activities. Compounds 7a, 7g and 9a-c showed pronounced antimicrobial activity than standards. Some of the newly synthesized compounds were evaluated for antioxidant activity. Compounds lc, 5c and 8c displayed promising free radical scavenging activity and found to be more potent than standard, ascorbic acid (vitamin C). (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：591 / 600
页数：10
相关论文
共 50 条
  • [1] Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives
    Mohamed, Mosaad Sayed
    Awad, Samir Mohamed
    Ahmed, Naglaa Mohamed
    ACTA PHARMACEUTICA, 2011, 61 (02) : 171 - 185
  • [2] Synthesis and Bioactivity Evaluation of New 6-Aryl-5-cyano Thiouracils as Potential Antimicrobial and Anticancer Agents
    Taher, Azza Taher
    Abou-Seri, Sahar Mahmoud
    MOLECULES, 2012, 17 (08) : 9868 - 9886
  • [3] Synthesis and biological evaluation of novel pyrimidines derived from 6-aryl-5-cyano-2-thiouracil
    Mahran, Asma Mohamed
    Hassan, Nasser Abdelhamid
    Osman, Dalia Ahmed A.
    Ragab, Sherif Shaban
    Hassan, Allam Abdelhamid
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2016, 71 (5-6): : 133 - 140
  • [4] A concise synthesis of pyrimidinophanes from 6-aryl-5-cyano-2-thiouracil
    Upadhyay, DN
    Agarwal, N
    Goel, A
    Ram, VJ
    JOURNAL OF CHEMICAL RESEARCH, 2003, (06) : 380 - 382
  • [5] Synthesis of novel spiropiperidine derivatives and their antimicrobial and antioxidant activities
    Srinivasan, Rajagopalan
    Narayana, Badiadka
    Sarojini, Balladka Kunhanna
    Raj, Channa Govindaraju Darshan
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (11): : 1391 - 1408
  • [6] Synthesis, Antioxidant and Antimicrobial Activities of Metal Complexes of 2-Thiouracil-Hydroxyquinoline Derivatives
    Worachartcheewan, Apilak
    Pingaew, Ratchanok
    Lekcharoen, Decha
    Prachayasittikul, Supaluk
    Ruchirawat, Somsak
    Prachayasittikul, Virapong
    LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (06) : 602 - 611
  • [7] CHEMOTHERAPEUTICAL AGENTS .5. SYNTHESES AND ACTIVITIES OF NOVEL PYRIMIDINES DERIVED FROM 5-CYANO-6-ARYL-2-THIOURACIL
    RAM, VJ
    VANDENBERGHE, DA
    VLIETINCK, AJ
    LIEBIGS ANNALEN DER CHEMIE, 1987, (09): : 797 - 801
  • [8] SYNTHESIS AND CHEMOTHERAPEUTICAL ACTIVITY OF 5-CYANO-6-ARYLURACIL AND 2-THIOURACIL DERIVATIVES
    RAM, VJ
    VLIETINCK, AJ
    VANDENBERGHE, DA
    HETEROCYCLES, 1984, 21 : 781 - 781
  • [9] Novel Mannich Base Derivatives: Synthesis, Characterization, Antimicrobial and Antioxidant Activities
    Kotan, Gul
    LETTERS IN ORGANIC CHEMISTRY, 2021, 18 (10) : 830 - 841
  • [10] Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors
    Bamba, Fante
    Jin, Jinshan
    Tai, Phang C.
    Wang, Binghe
    HETEROCYCLIC COMMUNICATIONS, 2020, 26 (01) : 76 - 83
12345