An efficient, one-pot three-component synthesis of 4H-thiazolo[3,2-a][1,3,5]triazin-6-one derivatives

被引：4
|
作者：
Ubeid, Mustafa T. [1 ]
Thabet, Hamdy K. [1 ,2 ]
El-Feky, Said A. [3 ]
机构：
[1] Northern Border Univ, Fac Arts & Sci, Dept Chem, PO 840, Rafha 91911, Saudi Arabia
[2] Al Azhar Univ, Fac Sci, Dept Chem, Cairo 11284, Egypt
[3] Northern Border Univ, Fac Pharm, Dept Pharmaceut Chem, PO 840, Rafha 91911, Saudi Arabia
来源：
HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 01期
关键词：
multicomponent reaction; one-pot reaction; thiazolo[3,2-a][1,3,5]triazin-6-ones; MULTICOMPONENT REACTION; BIOLOGICAL EVALUATION; PFITZINGER REACTION; SOLVENT-FREE; DISCOVERY; PYRAZOLE;
D O I：
10.1515/hc-2015-0135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient protocol was established to synthesize thiazolo[3,2-a][1,3,5]triazin-6-ones via three-component one-pot condensation reaction of readily available thioglycolic acid or ethyl thioglycolate, aldehydes or ketones and dicyandiamide in the presence of ammonium acetate. All of the newly synthesized compounds were characterized by spectroscopic analyses.
引用
收藏
页码：43 / 47
页数：5
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