Pivotal Role of the Genital Epithelial Cells in HIV-1 Transmission

被引：1
|
作者：
De Saint Jean, Amelie [1 ]
Bourlet, Thomas [1 ,2 ]
Delezay, Olivier [1 ]
机构：
[1] Univ St Etienne, Fac Med J Lisfranc, GIMAP, COMUE Lyon,GIMAP Res Unit, St Etienne, France
[2] CHU St Etienne, Serv Agents Infect & Hyg, St Etienne, France
来源：
CURRENT HIV RESEARCH | 2015年 / 13卷 / 06期
关键词：
Epithelial cells; female genital tract; HIV-1; innate immunity; microbicides; semen; sexually transmitted agents; HUMAN-IMMUNODEFICIENCY-VIRUS; LEUKOCYTE PROTEASE INHIBITOR; FEMALE REPRODUCTIVE-TRACT; SEXUALLY-TRANSMITTED-DISEASES; JUNCTION MOLECULE NECTIN-1; HUMAN VAGINAL HISTOLOGY; SEMEN-DERIVED ENHANCER; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; MEDROXYPROGESTERONE ACETATE;
D O I：
10.2174/1570162X13666150624100339
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
AIDS remains one of the world's most serious health challenges, with 35 million people living with HIV worldwide at the end of 2013. HIV sexual transmission accounts for the overwhelming majority of people newly infected, making genital and rectal mucosal tissues the major sites of infection. This review focuses on the role of the female genital epithelial cells in the establishment of HIV infection.
引用
收藏
页码：479 / 489
页数：11
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