One-Pot Synthesis of Fused [1,6]Naphthyridine Derivatives via Three-Component Reaction

A simple, convenient, and eco-friendly synthetic protocol has been developed via a one-pot three-component reaction between 2-chloroquinoline-4-amines, different substituted aromatic aldehydes, and malononitrile using ethanol as reaction medium. Employing this protocol, a series of 5-chloro-4-phenyl benzo[f][1,6] naphthyridine-2-amino-3-carbonitrile derivatives were synthesized in an environmentally friendly approach under operational simplicity, short time reactions, easy work-up procedure, and comparatively high yields. This chemistry provides a convenient and promising synthetic strategy for the construction of the napthyridine skeleton. All synthesized compounds were identified on the basis of their spectral data.