14-3-3 Proteins in Glutamatergic Synapses

被引：30
|
作者：
Zhang, Jiajing [1 ]
Zhou, Yi [1 ]
机构：
[1] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
来源：
NEURAL PLASTICITY | 2018年 / 2018卷
关键词：
LONG-TERM POTENTIATION; RECEPTOR TRAFFICKING; SYNAPTIC PLASTICITY; KAINATE RECEPTORS; NMDA RECEPTORS; PHOSPHORYLATION; KINASE; INACTIVATION; RIM1-ALPHA; 14-3-3-EPSILON;
D O I：
10.1155/2018/8407609
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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页数：6
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