Discovery of Swine as a Host for the Reston ebolavirus

被引：251

作者：

Barrette, Roger W. ^{[1
]}

Metwally, Samia A. ^{[1
]}

Rowland, Jessica M. ^{[1
]}

Xu, Lizhe ^{[1
]}

Zaki, Sherif R. ^{[2
,3
]}

Nichol, Stuart T. ^{[2
,3
]}

Rollin, Pierre E. ^{[2
,3
]}

Towner, Jonathan S. ^{[2
,3
]}

Shieh, Wun-Ju ^{[2
,3
]}

Batten, Brigid ^{[2
,3
]}

Sealy, Tara K. ^{[2
,3
]}

Carrillo, Consuelo ^{[1
]}

Moran, Karen E. ^{[1
]}

Bracht, Alexa J. ^{[1
]}

Mayr, Gregory A. ^{[1
]}

Sirios-Cruz, Magdalena ^{[4
]}

Catbagan, Davinio P. ^{[4
]}

Lautner, Elizabeth A. ^{[1
]}

Ksiazek, Thomas G. ^{[2
,3
]}

White, William R. ^{[1
]}

McIntosh, Michael T. ^{[1
]}

机构：

[1] USDA, Plum Isl Anim Dis Ctr, US Anim & Plant Hlth Inspect Serv, Natl Vet Serv Labs,Foreign Anim Dis Diagnost Lab, Greenport, NY 11944 USA

[2] Ctr Dis Control & Prevent, Special Pathogens Branch, Atlanta, GA 30333 USA

[3] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA

[4] Dept Agr, Bur Anim Ind, Quezon City 1101, Philippines

来源：

SCIENCE | 2009年 / 325卷 / 5937期

关键词：

VIRUS; BATS; PHILIPPINES; RESERVOIRS; INFECTION; VIRULENCE; EMERGENCE;

D O I：

10.1126/science.1172705

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

引用

页码：204 / 206

页数：3

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