Concerns with beta2-agonists in pediatric asthma - a clinical perspective

被引：13
|
作者：
Kersten, Elin T. G. [1 ]
Koppelman, Gerard H. [1 ]
Thio, Bernard J. [2 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol,GRIAC Res, POB 30-001, NL-9700 RB Groningen, Netherlands
[2] Medisch Spectrum Twente, Dept Pediat, NL-7512 KZ Enschede, Netherlands
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2017年 / 21卷
关键词：
beta; 2-agonists; Tolerance; Asthma; Genetic polymorphisms; LONG-ACTING BETA(2)-AGONISTS; AGE-RELATED-CHANGES; BETA-AGONISTS; UNITED-STATES; SALMETEROL; FORMOTEROL; CHILDREN; MORTALITY; THERAPY; BETA(2)-ADRENOCEPTOR;
D O I：
10.1016/j.prrv.2016.05.006
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Beta2-adrenoreceptor agonists (beta 2-agonists) are extensively used in the treatment of childhood asthma. However, there have been concerns regarding their adverse effects and safety. In 2005, the FDA commissioned a "Black Box Warning" communicating the potential for an increased risk for serious asthma exacerbations or asthma related deaths, with the regular use of LABAs. In a meta-analysis of controlled clinical trials, the incidence of severe adverse events appeared to be highest in the 4-11 year age group. Several mechanisms have been proposed regarding the risk of regular use of beta 2-agonists, such as masking patients' perception of worsening asthma, desensitization and downregulation of the beta 2-adrenoreceptor, pro-inflammatory effects of beta 2-agonists, pharmacogenetic effects of beta 2-adrenoreceptor polymorphisms and age related differences in pathophysiology of asthma. In this paper, we review beta 2-receptor pharmacology, discuss the concerns regarding treatment with beta 2-agonists in childhood asthma, and provide suggestions for clinical pediatric practice in the light of current literature. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：80 / 85
页数：6
相关论文
共 50 条
  • [31] Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children
    Griffiths, Benedict
    Ducharme, Francine M.
    PAEDIATRIC RESPIRATORY REVIEWS, 2013, 14 (04) : 234 - 235
  • [32] EXPERIENCES WITH LARGE DOSES OF BETA2-AGONISTS INHALED FROM NEBULIZERS
    LARSSON, S
    POSTGRADUATE MEDICAL JOURNAL, 1983, 59 : 71 - 72
  • [33] Anabolic and lipolytic actions of beta2-agonists in humans and antidoping challenges
    Hostrup, Morten
    Jacobson, Glenn A.
    Jessen, Soren
    Lemminger, Anders Krogh
    DRUG TESTING AND ANALYSIS, 2020, 12 (05) : 597 - 609
  • [34] Inhaled beta2-agonists increase power development in elite athletes
    Hostrup, Morten
    Kalsen, Anders
    Kreiberg, Michael
    Bangsbo, Jens
    Backer, Vibeke
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [35] Combination therapy of inhaled steroids and long-acting beta2-agonists in asthma-COPD overlap syndrome
    Lee, Suh-Young
    Park, Hye Yun
    Kim, Eun Kyung
    Lim, Seong Yong
    Rhee, Chin Kook
    Hwang, Yong Il
    Oh, Yeon-Mok
    Do Lee, Sang
    Park, Yong Bum
    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2016, 11 : 2797 - 2803
  • [36] Beta2-agonists Use during Pregnancy and the Risk of Congenital Malformations
    Eltonsy, Sherif
    Forget, Amelie
    Blais, Lucie
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2011, 91 (11) : 937 - 947
  • [37] Combination therapy of inhaled steroids and long-acting beta2-agonists in asthma-COPD overlap syndrome
    Lee, S-Y
    Park, H. Y.
    Ko, Y.
    Park, S. Y.
    Mo, E. K.
    Yoo, K. H.
    Park, Y. B.
    ALLERGY, 2016, 71 : 260 - 260
  • [38] Asthma Mortality and Long-Acting Beta2-Agonists in Five Major European Countries, 1994-2004
    Chatenoud, Liliane
    Malvezzi, Matteo
    Pitrelli, Andrea
    La Vecchia, Carlo
    Bamfi, Francesco
    JOURNAL OF ASTHMA, 2009, 46 (06) : 546 - 551
  • [39] FEV1 Improvements with Tiotropium & Long-Acting Beta2-Agonists Added to Inhaled Corticosteroid Therapy Are Similar in Pediatric Patients with Asthma.
    Vogelberg, C.
    Goldstein, S.
    Graham, L.
    Szefler, S.
    El Azzi, G.
    Kallsen, K.
    Hamelmann, E.
    PEDIATRIC PULMONOLOGY, 2018, 53 : S97 - S100
  • [40] Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma
    Ni Chroinin, M.
    Greenstone, I. R.
    Danish, A.
    Magdolinos, H.
    Masse, V
    Zhang, X.
    Ducharme, F. M.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2005, (04):
12345