C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas

被引：13
|
作者：
Jacobson, Caron A. [1 ]
Maus, Marcela, V [2 ]
机构：
[1] Dana Farber Canc Inst, 450 Brookline Ave, Boston, MA 02215 USA
[2] Massachusetts Gen Hosp, Boston, MA 02114 USA
来源：
BLOOD ADVANCES | 2020年 / 4卷 / 22期
关键词：
INHIBITOR IBRUTINIB; MALIGNANCIES; POPULATION; EFFICACY; OUTCOMES; BTK;
D O I：
10.1182/bloodadvances.2020003391
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 has transformed the natural history of relapsed and refractory B-cell acute lymphoblastic leukemia and aggressive B-cell non-Hodgkin lymphoma. Based on these results, CD19 CAR T cells have since been tested in largely incurable lymphomas, including mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma, with promising early results that raise the question of whether this cellular immunotherapy could have curative potential and change the natural history of these diseases. This article reviews these results and this hypothesis.
引用
收藏
页码：5858 / 5862
页数：5
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