Antioxidants as an Epidermal Stem Cell Activator

被引：9

作者：

Kwon, Soon-Hyo ^{[1
]}

Park, Kyoung-Chan ^{[2
]}

机构：

[1] Kyung Hee Univ, Kyung Hee Univ Hosp Gang Dong, Sch Med, Dept Dermatol, Seoul 05278, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Dermatol, Gyeonggi 13620, South Korea

来源：

ANTIOXIDANTS | 2020年 / 9卷 / 10期

关键词：

antioxidants; epidermal stem cell; extracellular matrix; niche; skin equivalent; GANODERMA-LUCIDUM POLYSACCHARIDES; COPPER COMPLEX GLYCYL-L-HISTIDYL-L-LYSINE-CU2+; INDUCED OXIDATIVE DAMAGE; FREE-RADICAL DAMAGE; L-ASCORBIC-ACID; HYALURONIC-ACID; VITAMIN-C; DNA DEMETHYLATION; SUPEROXIDE-DISMUTASE; GRANULATION-TISSUE;

D O I：

10.3390/antiox9100958

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidants may modulate the microenvironment of epidermal stem cells by reducing the production of reactive oxygen species or by regulating the expression of extracellular matrix protein. The extracellular membrane is an important component of the stem cell niche, and microRNAs regulate extracellular membrane-mediated basal keratinocyte proliferation. In this narrative review, we will discuss several antioxidants such as ascorbic acid, plant extracts, peptides and hyaluronic acid, and their effect on the epidermal stem cell niche and the proliferative potential of interfollicular epidermal stem cells in 3D skin equivalent models.

引用

页码：1 / 23

页数：22

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