In Situ Mixed Donor Synthesis of Ampicillin with Ethylene Glycol Co-Solvent

被引：7

作者：

Deaguero, Andria L. ^{[1
]}

Bommarius, Andreas S. ^{[2
]}

机构：

[1] Sch Chem & Biomol Engn, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA USA

[2] Georgia Inst Technol, Sch Chem & Biochem, Sch Chem & Biomol Engn, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2014年 / 111卷 / 05期

关键词：

-lactam antibiotics; ampicillin; transesterification; co-solvent; IMMOBILIZED PENICILLIN ACYLASE; KINETICALLY CONTROLLED SYNTHESIS; HIGH SUBSTRATE CONCENTRATIONS; CATALYZED SYNTHESIS; ORGANIC COSOLVENTS; CEPHALEXIN; OPTIMIZATION; METHANOL; SOLVENTS; ENZYME;

D O I：

10.1002/bit.25143

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ethylene glycol has the ability to act as a reactant when employed as a co-solvent for the enzymatic synthesis of ampicillin from (R)-phenylglycine methyl ester and 6-aminopenicillanic acid. The side reaction positively affects yield because its product, (R)-phenylglycine hydroxyethyl ester, is an intermediate for ampicillin synthesis. Biotechnol. Biotechnol. Bioeng. 2014;111: 1054-1058. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1054 / 1058

页数：5

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