Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

被引：162

作者：

Stobart, Jillian L. ^{[1
,2
,3
,4
]}

Ferrari, Kim David ^{[1
,2
,3
]}

Barrett, Matthew J. P. ^{[1
,2
,3
]}

Gluck, Chaim ^{[1
,2
,3
]}

Stobart, Michael J. ^{[1
,2
,3
]}

Zuend, Marc ^{[1
,2
,3
]}

Weber, Bruno ^{[1
,2
,3
]}

机构：

[1] Univ Zurich, Inst Pharmacol & Toxicol, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Neurosci Ctr, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[3] ETH, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[4] Univ Manitoba, Coll Pharm, 750 McDermot Ave, Winnipeg, MB R3E 0T5, Canada

来源：

NEURON | 2018年 / 98卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

CA2+; PLASTICITY; RESPONSES; MODULATION; ACTIVATION; TRANSIENTS; DYNAMICS; RELEASE; CORTEX;

D O I：

10.1016/j.neuron.2018.03.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sensory stimulation evokes intracellular calcium signals in astrocytes; however, the timing of these signals is disputed. Here, we used novel combinations of genetically encoded calcium indicators for concurrent two-photon imaging of cortical astrocytes and neurons in awake mice during whisker deflection. We identified calcium responses in both astrocyte processes and endfeet that rapidly followed neuronal events (similar to 120 ms after). These fast astrocyte responses were largely independent of IP(3)R2-mediated signaling and known neuromodulator activity (acetylcholine, serotonin, and norepinephrine), suggesting that they are evoked by local synaptic activity. The existence of such rapid signals implies that astrocytes are fast enough to play a role in synaptic modulation and neurovascular coupling.

引用

页码：726 / +

页数：14