Na+,K+-ATPase activity in an animal model of mania

被引：23

作者：

Zugno, Alexandra I. ^{[2
]}

Valvassori, Samira S. ^{[2
]}

Scherer, Emilene B. S. ^{[3
]}

Mattos, Cristiane ^{[3
]}

Matte, Cristiane ^{[3
]}

Ferreira, Camila L. ^{[2
]}

Rezin, Gislaine T. ^{[1
]}

Wyse, Angela T. S. ^{[3
]}

Quevedo, Joao ^{[2
]}

Streck, Emilio L. ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Lab Neurociencias, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Criciuma, SC, Brazil

[3] Univ Fed Rio Grande do Sul, Lab Erros Inatos Metab, Dept Bioquim, Inst Ciencias Basicas Saude, Porto Alegre, RS, Brazil

来源：

JOURNAL OF NEURAL TRANSMISSION | 2009年 / 116卷 / 04期

关键词：

Na+; K+-ATPase; Mania; Amphetamine; Lithium; Valproate; K+-ATPASE ACTIVITY; MITOCHONDRIAL DYSFUNCTION; SIGNAL-TRANSDUCTION; SYNTHASE KINASE-3; MOOD STABILIZERS; BIPOLAR DISORDER; ARACHIDONIC-ACID; BRAIN; HIPPOCAMPUS; INHIBITION;

D O I：

10.1007/s00702-009-0198-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated Na+,K+-ATPase activity in hippocampus of rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine or saline was administered to rats for 14 days, between day 8 and 14, rats were treated with lithium, valproate or saline. In the maintenance treatment, rats were treated with lithium, valproate or saline, between day 8 and 14, amphetamine or saline were administered. Locomotor activity was assessed by open field test and Na+,K+-ATPase activity was measured. Our results showed that mood stabilizers reversed and prevented amphetamine-induced behavioral effects. Moreover, amphetamine (acute treatment) increased Na+,K+-ATPase activity, and administration of lithium or valproate reversed this effect. In the maintenance treatment, amphetamine increased Na+,K+-ATPase activity in saline-pretreated rats. Amphetamine administration in lithium- or valproate-pretreated animals did not alter Na+,K+-ATPase activity. The findings suggest that amphetamine-induced hyperactivity may be associated with an increase in Na+,K+-ATPase.

引用

页码：431 / 436

页数：6

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