Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

被引：40

作者：

Xu, Yi-Sheng ^{[1
,2
]}

Zeng, Cheng-Chu ^{[1
]}

Jiao, Zi-Guo ^{[1
]}

Hu, Li-Ming ^{[1
]}

Zhong, Ru-gang ^{[1
]}

机构：

[1] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

[2] Chinese Res Inst Environm Sci, Atmospher Chem & Aerosol Res Dept, Beijing 100012, Peoples R China

来源：

MOLECULES | 2009年 / 14卷 / 02期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives; HIV-1; integrase; Mg2+ binding; Aryl diketo acids; QUINOXALONE DERIVATIVES; STRAND TRANSFER; INHIBITORS; REPLICATION; MECHANISM; PLATFORM; THERAPY; ENZYMES; BINDING; CELLS;

D O I：

10.3390/molecules14020868

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by H-1-NMR, C-13-NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.

引用

页码：868 / 883

页数：16

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