Advances in the Treatment of Food Allergy Sublingual and Epicutaneous Immunotherapy

被引：18
|
作者：
Sindher, Sayantani [1 ]
Fleischer, David M. [2 ]
Spergel, Jonathan M. [1 ]
机构：
[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Allergy & Immunol,Dept Pediat, Philadelphia, PA 19104 USA
[2] Univ Colorado, Denver Sch Med, Childrens Hosp Colorado, Sect Allergy,Dept Pediat, Aurora, CO 80045 USA
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 01期
关键词：
Allergen immunotherapy (AIT); Sublingual immunotherapy (SLIT); Epicutaneous immunotherapy (EPIT); Food allergy; Desensitization; Oral tolerance; Sustained unresponsiveness; REGULATORY T-CELLS; PEANUT ALLERGY; ORAL IMMUNOTHERAPY; DOUBLE-BLIND; MULTICENTER TRIAL; NATURAL-HISTORY; SENSITIZED MICE; MILK ALLERGY; INTACT SKIN; KIWI FRUIT;
D O I：
10.1016/j.iac.2015.08.008
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Food allergies continue to increase in prevalence. Allergen immunotherapy has the most potential in treating food allergy. Oral immunotherapy, though efficacious, has a high rate of adverse reactions. Sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT) have emerged in the search for safer therapeutic options and can successfully desensitize patients with food allergies. SLIT uses the tolerogenic environment of the oral mucosa and epicutaneous immunotherapy (EPIT) uses the immune cells of the epidermis to transport antigens to afferent lymph nodes to activate immune responses. More research is needed to define optimal doses and administration protocols.
引用
收藏
页码：39 / +
页数：17
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