LTα, TNF, and ILC3 in Peyer's Patch Organogenesis

被引：8

作者：

Gogoleva, Violetta S. ^{[1
]}

Kuprash, Dmitry, V ^{[1
]}

Grivennikov, Sergei, I ^{[1
,8
,9
]}

Tumanov, Alexei, V ^{[2
]}

Kruglov, Andrey A. ^{[1
,3
,4
,5
]}

Nedospasov, Sergei A. ^{[1
,3
,4
,6
,7
]}

机构：

[1] Russian Acad Sci, Ctr Precis Genome Editing & Genet Technol Biomed, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA

[3] Lomonosov Moscow State Univ, Belozersky Inst Phys Chem Biol, Moscow 119234, Russia

[4] Lomonosov Moscow State Univ, Fac Biol, Moscow 119234, Russia

[5] Deutsch Rheuma Forschungszentrum DRFZ, AG Chron Inflammat, D-10117 Berlin, Germany

[6] Charite, Inst Cell Biol & Neurobiol, D-10117 Berlin, Germany

[7] Sirius Univ Sci & Technol, Div Immunobiol & Biomed, Fede Territory Sirius 35340, Russia

[8] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[9] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA

来源：

CELLS | 2022年 / 11卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

TNF; lymphotoxin; Peyer's patches; lymphoid tissue organogenesis; innate lymphoid cells; TUMOR-NECROSIS-FACTOR; LYMPHOTOXIN-BETA-RECEPTOR; INNATE LYMPHOID-CELLS; MICE DEFICIENT; DISTINCT ROLES; ABNORMAL-DEVELOPMENT; GENE-EXPRESSION; KNOCKOUT MICE; FAMILY; MEMBER;

D O I：

10.3390/cells11121970

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TNF and LT alpha are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer's patch organogenesis.

引用

页数：11

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