Chemistry of oligonucleotide-gold nanoparticle conjugates

被引：9

作者：

Letsinger, RL ^{[1
]}

Mirkin, CA ^{[1
]}

Elghanian, R ^{[1
]}

Mucic, RC ^{[1
]}

Storhoff, JJ ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 144卷

基金：

美国国家科学基金会;

关键词：

gold; nanoparticles; oligonucleotide; hybridization; non-radioactive detection;

D O I：

10.1080/10426509908546255

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Conjugates prepared by immobilizing thiol-terminated oligonucleotides onto gold nanoparticles form stable colloidal solutions in aqueous media. The oligonucleotides can serve as linkers to organize the gold particles reversibly into three dimensional assemblies, and the gold particles can function as colorimetric reporters for hybridization of the bound oligomers with target oligonucleotides in solution.

引用

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页码：359 / 362

页数：4

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