The role of F-box only protein 31 in cancer

被引：11
|
作者：
Tan, Yuyong [1 ]
Liu, Deliang [1 ]
Gong, Jian [1 ]
Liu, Jia [2 ]
Huo, Jirong [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Gastroenterol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Med Res Ctr, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
来源：
ONCOLOGY LETTERS | 2018年 / 15卷 / 04期
基金：
美国国家科学基金会;
关键词：
F-box protein; F-box only protein 31; tumorigenesis; DNA damage; ubiquitination; cell cycle; SQUAMOUS-CELL CARCINOMA; CYCLIN D1 DEGRADATION; SCF UBIQUITIN-LIGASE; ONCOGENE-INDUCED SENESCENCE; BREAST-CANCER; DNA-DAMAGE; TUMOR-SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; FBXO31;
D O I：
10.3892/ol.2018.7816
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
F-box only protein 31 (FBXO31), initially identified in 2005, is a novel subunit of the S-phase kinase associated protein 1-Cullin 1-F-box ubiquitin ligase. As with other F-box proteins, FBXO31 may interact with several proteins to promote their ubquitination and subsequent degradation in an F-box-dependent manner. It has been revealed that FBXO31 serves a crucial role in DNA damage response and tumorigenesis. However, the expression and function of FBXO31 varies in different types of human cancer. To the best of our knowledge, the present review is the first to summarize the role of FBXO31 in different types of human cancer and determine its underlying mechanisms, thereby paving the road for the design of FBXO31-targeted anticancer therapies.
引用
收藏
页码：4047 / 4052
页数：6
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