The role of F-box only protein 31 in cancer

被引：11
|
作者：
Tan, Yuyong [1 ]
Liu, Deliang [1 ]
Gong, Jian [1 ]
Liu, Jia [2 ]
Huo, Jirong [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Dept Gastroenterol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Med Res Ctr, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
来源：
ONCOLOGY LETTERS | 2018年 / 15卷 / 04期
基金：
美国国家科学基金会;
关键词：
F-box protein; F-box only protein 31; tumorigenesis; DNA damage; ubiquitination; cell cycle; SQUAMOUS-CELL CARCINOMA; CYCLIN D1 DEGRADATION; SCF UBIQUITIN-LIGASE; ONCOGENE-INDUCED SENESCENCE; BREAST-CANCER; DNA-DAMAGE; TUMOR-SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; FBXO31;
D O I：
10.3892/ol.2018.7816
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
F-box only protein 31 (FBXO31), initially identified in 2005, is a novel subunit of the S-phase kinase associated protein 1-Cullin 1-F-box ubiquitin ligase. As with other F-box proteins, FBXO31 may interact with several proteins to promote their ubquitination and subsequent degradation in an F-box-dependent manner. It has been revealed that FBXO31 serves a crucial role in DNA damage response and tumorigenesis. However, the expression and function of FBXO31 varies in different types of human cancer. To the best of our knowledge, the present review is the first to summarize the role of FBXO31 in different types of human cancer and determine its underlying mechanisms, thereby paving the road for the design of FBXO31-targeted anticancer therapies.
引用
收藏
页码：4047 / 4052
页数：6
相关论文
共 50 条
  • [1] F-box only protein 9 and its role in cancer
    Shujaat Hussain
    Jianshu Dong
    Xinli Ma
    Jian Li
    Shen Chen
    Agboybor Clement
    Hongmin Liu
    Molecular Biology Reports, 2022, 49 : 1537 - 1544
  • [2] F-box only protein 9 and its role in cancer
    Hussain, Shujaat
    Dong, Jianshu
    Ma, Xinli
    Li, Jian
    Chen, Shen
    Clement, Agboybor
    Liu, Hongmin
    MOLECULAR BIOLOGY REPORTS, 2022, 49 (02) : 1537 - 1544
  • [3] Role of an F-box protein in the Schwann cell
    Vasiliou, S
    Gillespie, S
    Johnson, RJ
    Court, F
    Sherman, DL
    Brophy, PJ
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 403A - 404A
  • [4] Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22
    Chen, Sen
    Ma, Shuangxin
    Yan, Jiaoyan
    Wang, Haiqing
    Ding, Bojiao
    Guo, Zihu
    Ma, Yaohua
    Chen, Xuetong
    Wang, Yonghua
    FRONTIERS IN ONCOLOGY, 2022, 11
  • [5] F-box only protein 9 is required for adipocyte differentiation
    Lee, Kyeong Won
    Kwak, Soo Heon
    Ahn, Byung Yong
    Lee, Hak Mo
    Jung, Hye Seung
    Cho, Young Min
    Park, Young Joo
    Chung, Sung Soo
    Park, Kyong Soo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 435 (02) : 239 - 243
  • [6] F-box protein interactions with the hallmark pathways in cancer
    Randle, Suzanne J.
    Laman, Heike
    SEMINARS IN CANCER BIOLOGY, 2016, 36 : 3 - 17
  • [7] The F-box protein family
    Kipreos, Edward T.
    Pagano, Michele
    GENOME BIOLOGY, 2000, 1 (05)
  • [8] The F-box protein family
    Edward T Kipreos
    Michele Pagano
    Genome Biology, 1
  • [9] F-Box Proteins and Cancer
    Yumimoto, Kanae
    Yamauchi, Yuhei
    Nakayama, Keiichi I.
    CANCERS, 2020, 12 (05)
  • [10] cDNA cloning and expression analysis of a novel human F-box only protein
    Cheng, HP
    Ma, YS
    Ni, XH
    Jiang, M
    Guo, LC
    Jin, W
    Xu, WW
    Cao, GT
    Ji, CN
    Ying, K
    Gu, SH
    Ma, YH
    Xie, Y
    Mao, YM
    MOLECULES AND CELLS, 2002, 14 (01) : 56 - 59
12345