Disposition and pharmacokinetics of a GalNAc3-Conjugated antisense oligonucleotide targeting human lipoprotein (a) in monkeys

被引:0
|
作者
不详
机构
关键词
Oligonucleotide; phosphorothioate; oligonucleotide conjugate; antisense; GalNAc; lipoprotein; pharmacokinetics; ISIS; 681257;
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:60 / 61
页数:2
相关论文
共 50 条
  • [21] Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry
    Husser, Christophe
    Brink, Andreas
    Zell, Manfred
    Mueller, Martina B.
    Koller, Erich
    Schadt, Simone
    ANALYTICAL CHEMISTRY, 2017, 89 (12) : 6821 - 6826
  • [22] Pharmacokinetics and Disposition of Heparin-Binding Growth Factor Midkine Antisense Oligonucleotide Nanoliposomes in Experimental Animal Species and Prediction of Human Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model
    Bai, Haihong
    Cheng, Yuanguo
    Che, Jinjing
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [23] Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol
    Schlegel, Anne
    Buhler, Cyril
    Devun, Flavien
    Agrario, Celine
    Urien, Saik
    Lokiec, Francois
    Sun, Jian-Sheng
    Dutreix, Marie
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2012, 1 : e33
  • [24] Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    Li, Wen-Chang
    Ye, Sheng-Long
    Sun, Rui-Xia
    Liu, Yin-Kun
    Tang, Zhao-You
    Kim, Youngsoo
    Karras, James G.
    Zhang, Hong
    CLINICAL CANCER RESEARCH, 2006, 12 (23) : 7140 - 7148
  • [25] Identification and Characterization of Solbinsiran, a GalNAc Conjugated siRNA Targeting Angiopoietin-Like 3
    Dudek, Hank
    Abrams, Marc
    Saxena, Utsav
    Turanov, Anton
    Brown, Bob
    Ruotolo, Giacomo
    Michael, Laura
    CIRCULATION, 2023, 148
  • [26] Hepatic fat changes with antisense oligonucleotide therapy targeting ANGPTL3
    Zimerman, Andre
    Wiviott, Stephen D.
    Park, Jeong-Gun
    Murphy, Sabina A.
    Ran, Xinhui
    Bramson, Candace R.
    Curto, Madelyn
    Ramos, Vesper
    Jevne, Alexandra
    Kuder, Julia F.
    Verma, Subodh
    Wojakowski, Wojtek
    Terra, Steven G.
    Sabatine, Marc S.
    Bergmark, Brian A.
    Marston, Nicholas A.
    JOURNAL OF CLINICAL LIPIDOLOGY, 2024, 18 (02) : e261 - e268
  • [27] ALG-020572, A GALNAC-CONJUGATED ANTISENSE OLIGONUCLEOTIDE, DEMONSTRATES IN VIVO EFFICACY AND FAVORABLE PRECLINICAL PROFILE FOR THE TREATMENT OF CHRONIC HEPATITIS B
    Gupta, Kusum
    HEPATOLOGY, 2021, 74 : 503A - 503A
  • [28] Antisense Oligonucleotide-Conjugated Nanostructure-Targeting lncRNA MALAT1 Inhibits Cancer Metastasis
    Gong, Ningqiang
    Teng, Xucong
    Li, Jinghong
    Liang, Xing-Jie
    ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (01) : 37 - 42
  • [29] Clinical pharmacokinetics and pharmacodynamics of G3139 (Genta Incorporated) antisense oligonucleotide targeting BCL-2.
    Fingert, HJ
    Klem, RE
    CLINICAL CANCER RESEARCH, 1999, 5 : 3847S - 3848S
  • [30] Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3
    Liu Chuan
    Wu Xiaohou
    Luo Chunli
    Hu Zili
    Yin Zhikang
    He Yunfeng
    Du Hu
    Zhang Weili
    Jiang Qing
    Lin Yanjun
    Journal of Experimental & Clinical Cancer Research, 29