Disposition and pharmacokinetics of a GalNAc3-Conjugated antisense oligonucleotide targeting human lipoprotein (a) in monkeys

被引：0
|
作者：
不详
机构：
来源：
CHIMICA OGGI-CHEMISTRY TODAY | 2018年 / 36卷 / 02期
关键词：
Oligonucleotide; phosphorothioate; oligonucleotide conjugate; antisense; GalNAc; lipoprotein; pharmacokinetics; ISIS; 681257;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：60 / 61
页数：2
相关论文
共 50 条
  • [1] Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys
    Yu, Rosie Z.
    Gunawan, Rudy
    Post, Noah
    Zanardi, Thomas
    Hall, Shannon
    Burkey, Jennifer
    Kim, Tae-Won
    Graham, Mark J.
    Prakash, Thazha P.
    Seth, Punit P.
    Swayze, Eric E.
    Geary, Richard S.
    Henry, Scott P.
    Wang, Yanfeng
    NUCLEIC ACID THERAPEUTICS, 2016, 26 (06) : 372 - 380
  • [2] Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice
    Yu, Rosie Z.
    Graham, Mark J.
    Post, Noah
    Riney, Stan
    Zanardi, Thomas
    Hall, Shannon
    Burkey, Jennifer
    Shemesh, Colby S.
    Prakash, Thazha P.
    Seth, Punit P.
    Swayze, Eric E.
    Geary, Richard S.
    Wang, Yanfeng
    Henry, Scott
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2016, 5 : e317
  • [3] Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys
    Shemesh, Colby S.
    Yu, Rosie Z.
    Gaus, Hans J.
    Greenlee, Sarah
    Post, Noah
    Schmidt, Karsten
    Migawa, Michael T.
    Seth, Punit P.
    Zanardi, Thomas A.
    Prakash, Thazha P.
    Swayze, Eric E.
    Henry, Scott P.
    Wang, Yanfeng
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2016, 5 : e319
  • [4] Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides
    Wang, Yanfeng
    Yu, Rosie Z.
    Henry, Scott
    Geary, Richard S.
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2019, 15 (06) : 475 - 485
  • [5] Pharmacokinetics of an antisense oligonucleotide injected intravitreally in monkeys
    Leeds, JM
    Henry, SP
    Bistner, S
    Scherrill, S
    Williams, K
    Levin, AA
    DRUG METABOLISM AND DISPOSITION, 1998, 26 (07) : 670 - 675
  • [6] Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey
    Yu, RZ
    Geary, RS
    Leeds, JM
    Watanabe, T
    Moore, M
    Fitchett, J
    Matson, J
    Burckin, T
    Templin, MV
    Levin, AA
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 90 (02) : 182 - 193
  • [7] Pharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomes
    Yu, RZ
    Geary, RS
    Leeds, JM
    Watanabe, T
    Fitchett, JR
    Matson, JE
    Mehta, R
    Hardee, GR
    Templin, MV
    Huang, K
    Newman, MS
    Quinn, Y
    Uster, P
    Zhu, G
    Working, PK
    Horner, M
    Nelson, J
    Levin, AA
    PHARMACEUTICAL RESEARCH, 1999, 16 (08) : 1309 - 1315
  • [8] Pharmacokinetics and Tissue Disposition in Monkeys of an Antisense Oligonucleotide Inhibitor of Ha-Ras Encapsulated in Stealth Liposomes
    Rosie Z. Yu
    Richard S. Geary
    Janet M. Leeds
    Tanya Watanabe
    Jonathon R. Fitchett
    John E. Matson
    Rahul Mehta
    Gregory R. Hardee
    Michael V. Templin
    Ken Huang
    Mary S. Newman
    Yoli Quinn
    Paul Uster
    George Zhu
    Peter K. Working
    Michelle Horner
    Joyce Nelson
    Arthur A. Levin
    Pharmaceutical Research, 1999, 16 : 1309 - 1315
  • [9] Integrated Assessment of Phase 2 Data on GalNAc3-Conjugated 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides
    Baker, Brenda F. F.
    Xia, Shuting
    Partridge, Wesley
    Kwoh, T. Jesse
    Tsimikas, Sotirios
    Bhanot, Sanjay
    Geary, Richard S. S.
    NUCLEIC ACID THERAPEUTICS, 2023, 33 (01) : 72 - 80
  • [10] Integrated Assessment of the Clinical Performance of GalNAc3-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience
    Crooke, Stanley T.
    Baker, Brenda F.
    Xia, Shuting
    Yu, Rosie Z.
    Viney, Nicholas J.
    Wang, Yanfeng
    Tsimikas, Sotirios
    Geary, Richard S.
    NUCLEIC ACID THERAPEUTICS, 2019, 29 (01) : 16 - 32
12345