Orthogonal functionalisation of α-helix mimetics

被引：23

作者：

Barnard, Anna ^{[1
,2
]}

Long, Kerya ^{[1
,2
]}

Yeo, David J. ^{[1
,2
]}

Miles, Jennifer A. ^{[1
,2
]}

Azzarito, Valeria ^{[1
,2
]}

Burslem, George M. ^{[1
,2
]}

Prabhakaran, Panchami ^{[1
,2
]}

Edwards, Thomas A. ^{[2
,3
]}

Wilson, Andrew J. ^{[1
,2
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct & Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Sch Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 35期

基金：

欧洲研究理事会;

关键词：

PROTEIN-PROTEIN INTERACTIONS; SOLID-PHASE; 1,3-DIPOLAR CYCLOADDITIONS; INHIBITORS; DESIGN; MCL-1; DERIVATIVES; ANTAGONISTS; DISRUPTION; MODULATORS;

D O I：

10.1039/c4ob00915k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide alpha-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.

引用

页码：6794 / 6799

页数：6

共 50 条

[41] Amphipathic α-Helix Mimetics Based on a 1,2-Diphenylacetylene Scaffold
Jung, Kwan-Young
Vanommeslaeghe, Kenno
Lanning, Maryanna E.
Yap, Jeremy L.
Gordon, Caryn
Wilder, Paul T.
MacKerell, Alexander D., Jr.
Fletcher, Steven
ORGANIC LETTERS, 2013, 15 (13) : 3234 - 3237
[42] Design and Synthesis of a Prototype Scaffold for Five-Residue -Helix Mimetics
Bayly, Andrew R.
White, Andrew J. P.
Spivey, Alan C.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (25) : 5566 - 5569
[43] Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold
Marimganti, Srinivasa
Cheemala, Murthy N.
Ahn, Jung-Mo
ORGANIC LETTERS, 2009, 11 (19) : 4418 - 4421
[44] In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics
Lao, Brooke Bullock
Grishagin, Ivan
Mesallati, Hanah
Brewer, Thomas F.
Olenyuk, Bogdan Z.
Arora, Paramjit S.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (21) : 7531 - 7536
[45] MEDI 277-Novel α-helix mimetics with increased water solubility
Cummings, Christopher Gerald
Hamilton, Andrew D.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
[46] Conformationally Controlled sp3-Hydrocarbon-Based α-Helix Mimetics
Dewis, Lydia I.
Rudrakshula, Madhavachary
Williams, Christopher
Chiarparin, Elisabetta
Myers, Eddie L.
Butts, Craig P.
Aggarwal, Varinder K.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (23)
[47] Protein-Protein Interactions in Transcription: A Fertile Ground for Helix Mimetics
Guarracino, Danielle A.
Bullock, Brooke N.
Arora, Paramjit S.
BIOPOLYMERS, 2011, 95 (01) : 1 - 7
[48] Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation
Saraogi, Ishu
Hebda, James A.
Becerril, Jorge
Estroff, Lara A.
Miranker, Andrew D.
Hamilton, Andrew D.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (04) : 736 - 739
[49] Synthesis of substituted asymmetrical biphenyl amino esters as alpha helix mimetics
Williams, Anna B.
Hanson, Robert N.
TETRAHEDRON, 2012, 68 (27-28) : 5406 - 5414
[50] MACROCYCLIC PEPTIDE-PEPTOID HYBRIDS DESIGNED AS PPII HELIX MIMETICS
Liu, F.
Stephen, A.
Waheed, A.
Freed, E.
Fisher, R.
Burke, T., Jr.
BIOPOLYMERS, 2009, 92 (04) : 339 - 339

← 1 2 3 4 5 →