Preparation and Characterization of Porous Scaffolds Consisted of Hydroxyapatite, Polysaccharides and Collagen for Cartilage Tissue Engineering

被引：1
|
作者：
Adegawa, Takuro [1 ]
Ohyabu, Yoshimi [1 ,2 ]
Uemura, Toshimasa [2 ]
Yoshioka, Tomohiko [1 ]
Shinozaki, Kazuo [1 ]
Tanaka, Junzo [1 ]
机构：
[1] Tokyo Inst Technol, Dept Met & Ceram Sci, Meguro Ku, 2-12-1 S7-6, Tokyo 1528550, Japan
[2] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058562, Japan
来源：
BIOCERAMICS 21 | 2009年 / 396-398卷
关键词：
cartilage; scaffold; hydroxyapatite; polysaccharide; chondroitinsulfate; collagen; NANOCOMPOSITES; MATRICES; CELLS;
D O I：
10.4028/www.scientific.net/KEM.396-398.707
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Porous scaffolds, consisted of hydroxyapatite (HAp), chondroitinsulfate (ChS) and collagen, were prepared by freeze-drying technique. HAp/ChS composite particles were incorporated into a collagen matrix. Scanning electron microscope (SEM) observations showed that the porous scaffolds involved interconnected pores whose size was 80-200 mu m in diameter. The HAp/ChS particles were homogeneously distributed in the collagen matrix. Surface area of the scaffolds was increased by the incorporation of the particles. Compression tests in phosphate buffer saline indicated that the porous scaffolds had elastic property and had larger compressive modulus than the pure collagen scaffold. The porous scaffolds obtained in this study could be useful for a cartilage tissue engineering.
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页码：707 / 710
页数：4
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