Bioactive lipids and the control of Bax pro-apoptotic activity

被引：45
|
作者：
Mignard, V. [1 ,2 ]
Lalier, L. [1 ,2 ,3 ]
Paris, F. [1 ,2 ,3 ]
Vallette, F. M. [1 ,2 ,3 ]
机构：
[1] Ctr Rech Cancerol Nantes Angers, Nantes, France
[2] Univ Nantes, F-44007 Nantes, France
[3] Inst Cancerol Ouest, Nantes, France
来源：
CELL DEATH & DISEASE | 2014年 / 5卷
关键词：
Bax; sphingoside; prostaglandin; lipid; MITOCHONDRIAL OUTER MEMBRANES; BCL-2; FAMILY-MEMBER; SPHINGOSINE; 1-PHOSPHATE; CHANNEL FORMATION; STATINS ACTIVATE; CYTOCHROME-C; FATTY-ACIDS; CELL-DEATH; RAT-LIVER; CERAMIDE;
D O I：
10.1038/cddis.2014.226
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in the regulation of the activation and the integration of Bax into the mitochondrial outer membrane, a key pro-apoptotic member of the BCL-2 family. We describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for Bax to stimulate or inhibit its pro-death activity.
引用
收藏
页码：e1266 / e1266
页数：8
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