New Insights into the Mechanism of Action (MoA) of First-in-Class IgG-Based Bcma T-Cell Bispecific Antibody (TCB) for the Treatment of Multiple Myeloma (MM)

被引：5

作者：

Moreno, Laura ^{[1
]}

Zabaleta, Aintzane ^{[2
]}

Alignani, Diego ^{[2
]}

Lasa, Marta ^{[3
]}

Maiso, Patricia ^{[4
]}

Jelinek, Tomas ^{[2
]}

Segura, Victor ^{[5
]}

Delgado, Jose Antonio ^{[1
]}

Rodriguez-Otero, Paula ^{[2
]}

Prosper, Felipe ^{[2
]}

Strein, Klaus ^{[6
]}

Vu, Minh Diem ^{[6
]}

Miguel, Jesus San ^{[7
]}

Paiva, Bruno ^{[8
]}

机构：

[1] Univ Navarra Clin, Dept Hematol & Immunol, Pamplona, Spain

[2] Univ Navarra Clin, Pamplona, Spain

[3] CIMA, Pamplona, Spain

[4] Dana Farber Canc Inst, Med Oncol, Boston, MA USA

[5] CIMA UNAV IDISNA, Dept Bioinformat, Pamplona, Spain

[6] EngMab AG, Wilen, Switzerland

[7] CIMA UNAV IDISNA, Pamplona, Spain

[8] Univ Navarra, Ctr Invest Med Aplicada, Univ Navarra Clin, Pamplona, Spain

来源：

BLOOD | 2016年 / 128卷 / 22期

关键词：

D O I：

10.1182/blood.V128.22.2096.2096

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

2096

引用

页数：5

共 46 条

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[22] Updated results of a phase 1, first-in-human study of ABBV-383, a BCMA x CD3 bispecific T-cell redirecting antibody, in patients with relapsed/refractory multiple myeloma
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[23] Forimtamig, a novel GPRC5D-targeting T-cell bispecific antibody with a 2+1 format, for the treatment of multiple myeloma
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[24] Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms
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Amorim, Ricardo
Cornelissen, Ivo
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Moritsch, Stefan
Benedetti, Filippo
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[25] Immunotherapy based on bispecific T-cell engager with hIgG1 Fc sequence as a new therapeutic strategy in multiple myeloma
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CANCER SCIENCE, 2015, 106 (05) : 512 - 521
[26] Initial Results of a Phase I Study of TNB-383B, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in Relapsed/Refractory Multiple Myeloma
Rodriguez, Cesar
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BLOOD, 2020, 136
[27] ISB 2001, a First-in-Class Trispecific BCMA and CD38 T Cell Engager Designed to Overcome Mechanisms of Escape from Treatments for Multiple Myeloma By Targeting Two Antigens
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[28] A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo (vol 31, pg 1743, 2017)
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[29] Updated Safety and Efficacy Results of Abbv-383, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in a First-in-Human Phase 1 Study in Patients with Relapsed/Refractory Multiple Myeloma
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[30] The First-In-Class Anti-AXLxCD3ε Pronectin™-Based Bispecific T-Cell Engager Is Active in Preclinical Models of Human Soft Tissue and Bone Sarcomas
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