Role of Adhesion Molecules Early After Hypoxic-Ischemic Brain Injury in Preterm Lambs

被引：0
|
作者：
Alonso-Alconada, D. [1 ]
Alvarez, A. [1 ]
Goni de Cerio, F. [1 ]
Alvarez, F. J.
Rey-Santano, M. C.
Mielgo, V. E.
Valls i Soler, A.
Hilario, E. [1 ]
机构：
[1] Univ Basque Country, Sch Med, Bilbao, Spain
来源：
PROCEEDINGS OF THE XXI EUROPEAN CONGRESS OF PERINATAL MEDICINE | 2008年
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中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
To evaluate the expression levels of ICAM-1, VCAM-1, VLA-4 and fibronectin after brain injury induced by partial occlusion of the umbilical cord in fetal lambs. We found, in the first moments after HI brain injury, a decrease in the expression of these adhesion molecules, with the exception of the ICAM-1 whose levels showed no changes. These data suggest that de novo synthesized adhesion molecules will not be detected until after a period of 4 hours or more, whereas ICAM-1 maintains its expression in a constitutive form.
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页码：169 / 174
页数：6
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