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McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Resp Epidemiol & Clin Res Unit, Montreal Chest Inst, Montreal, PQ H3A 1A2, Canada McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Resp Epidemiol & Clin Res Unit, Montreal Chest Inst, Montreal, PQ H3A 1A2, Canada