On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions

被引:10
|
作者
Ruprecht, Klemens [1 ,2 ,3 ,4 ]
Mayer, Jens [5 ]
机构
[1] Charite Univ Med Berlin, Dept Neurol, D-10117 Berlin, Germany
[2] Free Univ Berlin, D-10117 Berlin, Germany
[3] Humboldt Univ, D-10117 Berlin, Germany
[4] Berlin Inst Hlth, D-10117 Berlin, Germany
[5] Univ Saarland, Med Fac, Inst Human Genet, D-66421 Homburg, Germany
关键词
ENDOGENOUS RETROVIRUS-W;
D O I
10.1073/pnas.1911703116
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:19791 / 19792
页数:2
相关论文
共 50 条
  • [21] Microglia-dependent neurodegeneration is fueled by HERV-W envelope protein in different mouse models of MS
    Gruchot, J.
    Leppert, D.
    Hartung, H-P
    Perron, H.
    Meyer, U.
    Kuery, P.
    MULTIPLE SCLEROSIS JOURNAL, 2025, 31 (1_SUPPL)
  • [22] MSRV/HERV-W gag protein: expression in brain endothelium of acute multiple sclerosis lesions in situ and induction by viral infection in cerebral endothelial cells in vitro
    Ruprecht, K
    Obojes, K
    Lassmann, H
    Wengel, V
    Schneider-Schaulies, J
    Perron, H
    Rieckmann, R
    MULTIPLE SCLEROSIS, 2004, 10 (7032): : S174 - S174
  • [23] Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment
    Gruchot, Joel
    Lewen, Isabel
    Dietrich, Michael
    Reiche, Laura
    Sindi, Mustafa
    Hecker, Christina
    Herrero, Felisa
    Charvet, Benjamin
    Weber-Stadlbauer, Ulrike
    Hartung, Hans-Peter
    Albrecht, Philipp
    Perron, Herve
    Meyer, Urs
    Kuery, Patrick
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (38)
  • [24] MSRV/HERV-W/syncytin and its linkage to multiple sclerosis: The usablity and the hazard of a human endogenous retrovirus
    Antonina Dolei
    Journal of NeuroVirology, 2005, 11 : 232 - 235
  • [25] MSRV/HERV-W/syncytin and its linkage to multiple sclerosis: The usablity and the hazard of a human endogenous retrovirus
    Dolei, A
    JOURNAL OF NEUROVIROLOGY, 2005, 11 (02) : 232 - 235
  • [26] Increased Expression of HERV-H ENV and HERV-W ENV Epitopes on the Surface of PBMCS from Patients with Active Multiple Sclerosis
    Brudek, T.
    Christensen, T.
    Petersen, T.
    Hansen, H. J.
    Moller-Larsen, A.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (11) : 1288 - 1289
  • [27] Modulating effect of HERV-W ENV on peripheral blood monocytes in patients with different types of multiple sclerosis
    Koliada, O. M.
    Vdovichenko, N., I
    Koliada, T., I
    Tupotilov, O., V
    PATHOLOGIA, 2022, 19 (01): : 32 - 39
  • [28] Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups
    Tarlinton, Rachael
    Wang, Belinda
    Morandi, Elena
    Gran, Bruno
    Khaiboullin, Timur
    Martynova, Ekatarina
    Rizvanov, Albert
    Khaiboullina, Svetlana
    FRONTIERS IN PHARMACOLOGY, 2020, 10
  • [29] The antibodies against the pathogenic pHERV-W envelope protein and the Clinical Forms of Multiple Sclerosis
    Ruberto, Stefano
    Dominguez-Mozo, Maria
    Garcia-Martinez, Maria
    Antonio Sechi, Leonardo
    Alvarez-Lafuente, Roberto
    MULTIPLE SCLEROSIS JOURNAL, 2024, 30 (03) : 875 - 875
  • [30] The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade
    Kremer, David
    Foerster, Moritz
    Schichel, Tanja
    Goettle, Peter
    Hartung, Hans-Peter
    Perron, Herve
    Kuery, Patrick
    MULTIPLE SCLEROSIS JOURNAL, 2015, 21 (09) : 1200 - 1203