Contrast-induced nephropathy: are there differences between low osmolar and iso-osmolar iodinated contrast media?

被引：31
|
作者：
Morcos, S. K. [1 ]
机构：
[1] No Gen Hosp, Dept Diagnost Imaging, Sheffield S5 7AU, S Yorkshire, England
来源：
CLINICAL RADIOLOGY | 2009年 / 64卷 / 05期
关键词：
CHRONIC KIDNEY-DISEASE; HIGH-RISK PATIENTS; DOUBLE-BLIND; RENAL-INSUFFICIENCY; IODIXANOL; NEPHROTOXICITY; ANGIOGRAPHY; AGENTS; TRIAL;
D O I：
10.1016/j.crad.2008.08.019
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
It is acknowledged that high osmolar contrast media are more nephrotoxic than low (LOCM) or iso-osmolar contrast media (IOCM). However, it remains contentious whether the IOCM are less nephrotoxic in comparison with LOCK This article reviews published clinical studies that investigated this issue and demonstrates there are no conclusive data to indicate that there is a definite difference in renal tolerance between LOCM and IOCM. All these agents are potentially nephrotoxic in patients with advanced renal impairment. In these patients the smallest possible dose of IOCM or LOCM should be used in addition to adequate hydration to minimize the risk of contrast nephropathy. (C) 2008 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：468 / 472
页数：5
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