1,2,3-Triazoles from carbonyl azides and alkynes: filling the gap

被引：27

作者：

Haldon, Estela ^{[1
]}

Alvarez, Eleuterio ^{[2
]}

Nicasio, M. Carmen ^{[3
]}

Perez, Pedro J. ^{[1
]}

机构：

[1] Univ Huelva, Dept Quim Ciencias Mat, CIQSO, Unidad Asociada CSIC,Lab Catalisis Homogenea, Huelva 21007, Spain

[2] Univ Seville, CSIC, Inst Invest Quim Isla Cartuja, Seville 41092, Spain

[3] Univ Seville, Dept Quim Inorgan, Seville 41071, Spain

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 64期

关键词：

CLICK CHEMISTRY; PIPERIDYL-1,2,3-TRIAZOLE UREAS; 1,3-DIPOLAR CYCLOADDITIONS; MEDICINAL CHEMISTRY; MATERIALS SCIENCE; TERMINAL ALKYNES; SULFONYL AZIDES; TRIAZOLE UREAS; INHIBITORS; OPTIMIZATION;

D O I：

10.1039/c4cc03614j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electron deficient azides are challenging substrates in CuAAC reactions. Particularly, when N-carbonyl azides are applied the formation of N-carbonyl triazoles has not yet been observed. We report herein the first example of this class of reaction, with a copper-based system that efficiently enables the synthesis of N-carbamoyl 1,2,3-triazoles by [3+2] cycloaddition of N-carbamoyl azides and alkynes.

引用

页码：8978 / 8981

页数：4

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