Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection

被引：36

作者：

Qiu, Lei ^{[1
]}

Song, Zhiqi ^{[1
]}

Setaluri, Vijayasaradhi ^{[2
]}

机构：

[1] Dalian Med Univ, Dept Dermatol, Affiliated Hosp 1, Dalian 116011, Peoples R China

[2] Univ Wisconsin, Dept Dermatol, Madison, WI 53706 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2014年 / 134卷 / 08期

关键词：

D O I：

10.1038/jid.2014.241

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired nuclear factor erythroid 2 related factor 2 (Nrf2)-antioxidant response element signaling and decreased activation of the antioxidant enzyme system. In patients with vitiligo, higher serum levels of IL-2 correlate with lower levels of hemeoxygenase-1, a product of the Nrf2 target gene.

引用

页码：2074 / 2076

页数：3

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