Evolution of translation termination factor eRF3: Is GSPT2 generated by retrotransposition of GSPT1's mRNA?

被引：12

作者：

Zhouravleva, G. ^{[1
]}

Schepachev, V.

Petrova, A.

Tarasov, O.

Inge-Vechtomov, S.

机构：

[1] St Petersburg State Univ, Dept Genet, St Petersburg 198904, Russia

[2] RAS, Vavilov Inst Gen Genet, St Petersburg Branch, St Petersburg, Russia

来源：

IUBMB LIFE | 2006年 / 58卷 / 04期

关键词：

evolution; translation termination; release factors; GSPT1; GSPT2; retroposition; intronless paralogue;

D O I：

10.1080/15216540600686862

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two release factors (eRF1 and eRF3) are responsible for correct termination of translation in eukaryotes. While the structure and functions of different domains of eRF1 have been sufficiently characterized, the role of eRF3 in translation termination remains unclear. Moreover, the N-terminal domain of eRF3, which is dispensable for termination, is highly divergent. Mammalian eRF3 exists in two isotypes, eRF3a and eRF3b, encoded by genes GSPT1 and GSPT2, respectively. Here we propose that GSPT2 originated through retrotransposition of processed GSPT1 transcript into the genome. Comparison of the 5' non-coding sequences of both genes revealed existence of potential promoter element in 5' UTR of GSPT1 which we suppose to be responsible for GSPT2 transcription.

引用

页码：199 / 202

页数：4

共 50 条

[31] eRF3a/GSPT1在常见肿瘤发生发展过程中的作用
习一清
杨丽洁
王丹雯
杨张朔
冯茂辉
谢伟
中华普通外科学文献(电子版), 2019, 13 (03) : 249 - 252
[32] TERMINATION OF TRANSLATION IN EUKARYOTES IS GOVERNED BY 2 INTERACTING POLYPEPTIDE-CHAIN RELEASE FACTORS, ERF1 AND ERF3
ZHOURAVLEVA, G
FROLOVA, L
LEGOFF, X
LEGUELLEC, R
INGEVECHTOMOV, S
KISSELEV, L
PHILIPPE, M
EMBO JOURNAL, 1995, 14 (16): : 4065 - 4072
[33] Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3
Hashimoto, Yoshifumi
Inagaki, Hiroto
Hoshino, Shin-ichi
FEBS LETTERS, 2015, 589 (17) : 2241 - 2247
[34] Increased tRNA concentration in yeast containing mutant termination translation factors eRF1 and eRF3
Zhouravleva, G. A.
Moskalenko, S. E.
Chabelskaya, S. V.
Philippe, M.
Inge-Vechtomov, S. G.
MOLECULAR BIOLOGY, 2006, 40 (04) : 724 - 730
[35] Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3
Zhouravleva G.A.
Moskalenko S.E.
Chabelskaya S.V.
Philippe M.
Inge-Vechtomov S.G.
Molecular Biology, 2006, 40 (4) : 647 - 653
[36] Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast
Valouev, Igor A.
Fominov, Gleb V.
Sokolova, Elizaveta E.
Smirnov, Vladimir N.
Ter-Avanesyan, Michael D.
BMC MOLECULAR BIOLOGY, 2009, 10
[37] The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor
Hashimoto, Yoshifumi
Kumagai, Naomichi
Hosoda, Nao
Hoshino, Shin-ichi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 445 (03) : 639 - 644
[38] Interaction between the poly(A)-binding protein Pab1 and the eukaryotic release factor eRF3 regulates translation termination but not mRNA decay in Saccharomyces cerevisiae
Roque, Sylvain
Cerciat, Marie
Gaugue, Isabelle
Mora, Liliana
Floch, Aurelie G.
de Zamaroczy, Miklos
Heurgue-Hamard, Valerie
Kervestin, Stephanie
RNA, 2015, 21 (01) : 124 - 134
[39] Termination of translation in eukaryotes is mediated by the quaternary eRF1•eRF3•GTP•Mg2+ complex.: The biological roles of eRF3 and prokaryotic RF3 are profoundly distinct
Mitkevich, Vladimir A.
Kononenko, Artem V.
Petrushanko, Irina Yu.
Yanvarev, Dmitry V.
Makarov, Alexander A.
Kisselev, Lev L.
NUCLEIC ACIDS RESEARCH, 2006, 34 (14) : 3947 - 3954
[40] C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction
Merkulova, TI
Frolova, LY
Lazar, M
Camonis, J
Kisselev, LL
FEBS LETTERS, 1999, 443 (01) : 41 - 47

← 1 2 3 4 5 →