Glutathione metabolism in uremic rat

被引：1
|
作者：
Rao, SVR
Indira, K
机构：
[1] Division of Molecular Biology, Department of Zoology, S.V.University, Tirupati - 517 502, A.P.
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1997年 / 20卷 / 03期
关键词：
D O I：
10.3109/01480549709003879
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The impact of guanidine hydrochloride, a uremic toxin, has been investigated on glutathione mediated antioxidant defense mechanisms in rat liver and kidney. Elevated glutathione-S-transferase (GST) activity in the tissue of guanidine treated rat indicates its active participation in the detoxification of uremic toxin involving glutathione: Glutathione (GSH) is replenished,by elevated glutathione reductase and peroxides formed are subsequently detoxified by augumented selenium and non-selenium dependent glutathione peroxidase activities.
引用
收藏
页码：229 / 237
页数：9
相关论文
共 50 条
  • [31] METABOLISM OF GLUTATHIONE
    BINKLEY, F
    NATURE, 1951, 167 (4257) : 888 - 889
  • [32] Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells
    Lash, LH
    Visarius, TM
    Sall, JM
    Qian, W
    Tokarz, JJ
    TOXICOLOGY, 1998, 130 (01) : 1 - 15
  • [33] CYSTATHIONASE ACTIVITY AND GLUTATHIONE METABOLISM IN REDIFFERENTIATING RAT HEPATOCYTE PRIMARY CULTURES
    MEREDITH, MJ
    CELL BIOLOGY AND TOXICOLOGY, 1987, 3 (04) : 361 - 377
  • [34] The effects of acute ethanol exposure and ageing on rat brain glutathione metabolism
    Sommavilla, Michela
    Sanchez-Villarejo, M. Victoria
    Almansa, Inmaculada
    Sanchez-Vallejo, Violeta
    Barcia, Jorge M.
    Romero, Francisco Javier
    Miranda, Maria
    FREE RADICAL RESEARCH, 2012, 46 (09) : 1076 - 1081
  • [35] STEREOSELECTIVITY OF GLUTATHIONE CONJUGATION - METABOLISM OF ALPHA-BROMOISOVALERYLUREA ENANTIOMERS IN THE RAT
    POLHUYS, M
    VONK, RJ
    MULDER, GJ
    KUIPERS, E
    HEPATOLOGY, 1988, 8 (05) : 1278 - 1278
  • [36] CIGARETTE-SMOKE, GLUTATHIONE METABOLISM AND EPITHELIAL PERMEABILITY IN RAT LUNGS
    RAHMAN, I
    LI, XY
    DONALDSON, K
    MACNEE, W
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (02) : S235 - S235
  • [37] Quinolinic acid lesion induces changes in rat striatal glutathione metabolism
    Cruz-Aguado, R
    Francis-Turner, L
    Díaz, CM
    Antúnez, I
    NEUROCHEMISTRY INTERNATIONAL, 2000, 37 (01) : 53 - 60
  • [38] In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor
    Thelwall, Peter E.
    Simpson, Nicholas E.
    Rabbani, Zahid N.
    Clark, M. Daniel
    Pourdeyhimi, Roxana
    Macdonald, Jeffrey M.
    Blackband, Stephen J.
    Gamcsik, Michael P.
    NMR IN BIOMEDICINE, 2012, 25 (02) : 271 - 278
  • [39] Metabolism of melphalan by rat liver microsomal glutathione S-transferase
    Zhang, J
    Ye, ZW
    Lou, YJ
    CHEMICO-BIOLOGICAL INTERACTIONS, 2005, 152 (2-3) : 101 - 106
  • [40] Evaluation of glutathione metabolism in cultured rat hepatocytes during acetanainophen injury
    Rousar, Tomas
    Kucera, Otto
    Krivakova, Pavla
    Lotkova, Halka
    Muzakova, Vladimira
    Cervinkova, Zuzana
    FREE RADICAL RESEARCH, 2007, 41 : S51 - S52
12345