Glutathione metabolism in uremic rat

被引：1
|
作者：
Rao, SVR
Indira, K
机构：
[1] Division of Molecular Biology, Department of Zoology, S.V.University, Tirupati - 517 502, A.P.
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1997年 / 20卷 / 03期
关键词：
D O I：
10.3109/01480549709003879
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The impact of guanidine hydrochloride, a uremic toxin, has been investigated on glutathione mediated antioxidant defense mechanisms in rat liver and kidney. Elevated glutathione-S-transferase (GST) activity in the tissue of guanidine treated rat indicates its active participation in the detoxification of uremic toxin involving glutathione: Glutathione (GSH) is replenished,by elevated glutathione reductase and peroxides formed are subsequently detoxified by augumented selenium and non-selenium dependent glutathione peroxidase activities.
引用
收藏
页码：229 / 237
页数：9
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