Discovery of AG-120: A first-in-class inhibitor of IDH1 mutant enzymes for the treatment of cancers harboring IDH1 mutations

被引：0

作者：

Popovici-Muller, Janeta ^{[1
]}

Lemieux, Rene ^{[2
]}

Saunders, Jeffrey ^{[3
]}

Salituro, Francesco ^{[4
]}

Yen, Katharine ^{[1
]}

Straley, Kimberly ^{[5
]}

Tobin, Erica ^{[1
]}

Wang, Fang ^{[1
]}

Gross, Stefan ^{[1
]}

Artin, Erin ^{[1
]}

Dang, Lenny ^{[1
]}

Yang, Hua ^{[1
]}

Utley, Luke ^{[6
]}

Chen, Yue ^{[1
]}

Olaharski, Andrew ^{[1
]}

Silverman, Lee ^{[1
]}

Agresta, Sam ^{[1
]}

Su, Michael ^{[1
]}

Biller, Scott ^{[1
]}

机构：

[1] Agios Pharmaceut, Cambridge, MA USA

[2] KSQ Therapeut, Cambridge, MA USA

[3] Resilience Therapeut, Boston, MA USA

[4] Sage Therapeut, Cambridge, MA USA

[5] Vertex Pharmaceut, Boston, MA USA

[6] Alnylam Pharmaceut, Cambridge, MA USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 252卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

268

引用

页数：1

共 50 条

[41] AG-120, a novel IDH1 targeted molecule, inhibits invasion and migration of chondrosarcoma cells in vitro
Heredia, V.
Mendiola, M.
Ortiz, E.
Bernabeu, D.
Pozo-Kreilinger, J. J.
Miguel, M.
Crespo, R.
Berjon, A.
Martinez-Marin, V.
Redondo, A.
ANNALS OF ONCOLOGY, 2017, 28
[42] The IDH1 inhibitor ivosidenib improved seizures in a patient with drug-resistant epilepsy from IDH1 mutant oligodendroglioma
Vo, Anh Huan
Ambady, Prakash
Spencer, David
EPILEPSY & BEHAVIOR REPORTS, 2022, 18
[43] Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor
Liang, Qianmao
Wang, Beilei
Zou, Fengming
Guo, Gongrui
Wang, Wenliang
Wang, Wei
Liu, Qingwang
Shen, Lijuan
Hu, Chen
Wang, Wenchao
Wang, Aoli
Huang, Tao
He, Yuying
Xia, Ruixiang
Ge, Jian
Liu, Jing
Liu, Qingsong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 256
[44] Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation
Wen, Fei
Gui, Gang
Wang, Xiaoyu
Qin, Anqi
Ma, Tianfang
Chen, Hui
Li, Chunzheng
Zha, Xiaoming
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (11) : 8667 - 8692
[45] Discovery of AG-221: A first-in-class inhibitor of IDH2 mutant enzymes for the treatment of acute myelogenous leukemia
Travins, Jeremy
Saunders, Jeffrey
Salituro, Francesco
Popovici-Muller, Janeta
Yen, Katharine
Straley, Kimberly
Hansen, Erica
Wang, Fang
Gross, Stefan
Dang, Lenny
Yang, Hua
Utley, Luke
Chen, Yue
Silverman, Lee
Agresta, Sam
Su, Michael
Biller, Scott
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[46] Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2
Ma, Rui
Yun, Cai-Hong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 503 (04) : 2912 - 2917
[47] A new era after a long wait: Vorasetinib, an inhibitor of mutant IDH1 and IDH2 enzymes in patients with IDH-mutant glioma
Silvani, Antonio
Franceschi, Enrico
TUMORI JOURNAL, 2024, 110 (03): : 160 - 161
[48] IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors
Molenaar, Remco J.
Radivoyevitch, Tomas
Nagata, Yasunobu
Khurshed, Mohammed
Przychodzen, Bartolomiej
Makishima, Hideki
Xu, Mingjiang
Bleeker, Fonnet E.
Wilmink, Johanna W.
Carraway, Hetty E.
Mukherjee, Sudipto
Sekeres, Mikkael A.
van Noorden, Cornelis J. F.
Maciejewski, Jaroslaw P.
CLINICAL CANCER RESEARCH, 2018, 24 (07) : 1705 - 1715
[49] A novel inhibitor of IDH1 abrogates 2-HG production and reverses aberrant epigenetic alterations in IDH1 mutant cells
Rominger, Cynthia
Quinn, Chad
Gao, Enoch
Pietrak, Beth
Rendina, Alan
Smallwood, Angela
Groy, Arthur
Korenchuk, Susan
McHugh, Charles
Wiggall, Ken
Reif, Alexander
Schmidt, Stanley
Qi, Hongwei
Zhao, Huizhen
Concha, Nestor
Carpenter, Christopher
Luengo, Juan
Kruger, Ryan
Schwartz, Benjamin
Adams, Nicholas
McCabe, Michael T.
CANCER RESEARCH, 2015, 75
[50] Extreme Vulnerability of IDH1 Mutant Cancers to NAD plus Depletion
Tateishi, Kensuke
Wakimoto, Hiroaki
Iafrate, A. John
Tanaka, Shota
Loebe, Franziska
Lelic, Nina
Wiederschain, Dmitri
Bedel, Olivier
Deng, Gejing
Zhang, Bailin
He, Timothy
Shi, Xu
Gerszten, Robert E.
Zhang, Yiyun
Yeh, Jing-Ruey J.
Curry, William T.
Zhao, Dan
Sundaram, Sudhandra
Nigim, Fares
Koerner, Mara V. A.
Ho, Quan
Fisher, David E.
Roider, Elisabeth M.
Kemeny, Lajos V.
Samuels, Yardena
Flaherty, Keith T.
Batchelor, Tracy T.
Chi, Andrew S.
Cahill, Daniel P.
CANCER CELL, 2015, 28 (06) : 773 - 784

← 1 2 3 4 5 →