Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

被引：79

作者：

Roehr, Susanne ^{[1
,2
]}

Pabst, Alexander ^{[1
]}

Riedel-Heller, Steffi G. ^{[1
]}

Jessen, Frank ^{[3
,4
]}

Turana, Yuda ^{[5
]}

Handajani, Yvonne S. ^{[6
]}

Brayne, Carol ^{[7
]}

Matthews, Fiona E. ^{[8
,9
]}

Stephan, Blossom C. M. ^{[9
]}

Lipton, Richard B. ^{[10
,11
,12
]}

Katz, Mindy J. ^{[10
]}

Wang, Cuiling ^{[11
]}

Guerchet, Maelenn ^{[13
,14
,15
]}

Preux, Pierre-Marie ^{[13
,14
,16
]}

Mbelesso, Pascal ^{[13
,14
,17
]}

Ritchie, Karen ^{[18
,19
]}

Ancelin, Marie-Laure ^{[18
]}

Carriere, Isabelle ^{[18
]}

Guaita, Antonio ^{[20
]}

Davin, Annalisa ^{[20
]}

Vaccaro, Roberta ^{[20
]}

Kim, Ki Woong ^{[21
,22
,23
]}

Han, Ji Won ^{[21
]}

Suh, Seung Wan ^{[22
]}

Shahar, Suzana ^{[24
]}

Din, Normah C. ^{[25
]}

Vanoh, Divya ^{[26
]}

van Boxtel, Martin ^{[27
]}

Koehler, Sebastian ^{[27
]}

Ganguli, Mary ^{[28
,29
,30
]}

Jacobsen, Erin P. ^{[28
]}

Snitz, Beth E. ^{[29
]}

Anstey, Kaarin J. ^{[31
,32
,33
]}

Cherbuin, Nicolas ^{[33
]}

Kumagai, Shuzo ^{[34
]}

Chen, Sanmei ^{[35
]}

Narazaki, Kenji ^{[36
]}

Ng, Tze Pin ^{[37
]}

Gao, Qi ^{[37
]}

Gwee, Xinyi ^{[37
]}

Brodaty, Henry ^{[38
,39
]}

Kochan, Nicole A. ^{[38
]}

Trollor, Julian ^{[38
,40
]}

Lobo, Antonio ^{[41
,42
,43
]}

Lopez-Anton, Raul ^{[41
,44
]}

Santabarbara, Javier ^{[41
,45
]}

Crawford, John D. ^{[38
]}

Lipnicki, Darren M. ^{[38
]}

Sachdev, Perminder S. ^{[38
,39
]}

机构：

[1] Univ Leipzig, Med Fac, Inst Social Med Occupat Hlth & Publ Hlth ISAP, Philipp Rosenthal Str 55, D-04103 Leipzig, Germany

[2] Trinity Coll Dublin, Global Brain Hlth Inst GBHI, Dublin, Ireland

[3] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[5] Atma Jaya Catholic Univ Indonesia, Sch Med, Dept Neurol, Jakarta, Indonesia

[6] Atma Jaya Catholic Univ Indonesia, Ctr Hlth Res, Sch Med, Jakarta, Indonesia

[7] Univ Cambridge, Cambridge Publ Hlth, Cambridge, England

[8] Univ Cambridge, Inst Publ Hlth, MRC Biostat Unit, Cambridge, England

[9] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England

[10] Yeshiva Univ, Albert Einstein Coll Med, Saul R Korey Dept Neurol, New York, NY USA

[11] Yeshiva Univ, Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA

[12] Yeshiva Univ, Albert Einstein Coll Med, Dept Psychiat & Behav Med, New York, NY USA

[13] INSERM, U1094, Trop Neuroepidemiol, Limoges, France

[14] Univ Limoges, Inst Epidemiol & Trop Neurol, GEIST, Trop Neuroepidemiol,U1094, Limoges, France

[15] IRD, Trop Neuroepidemiol, Associated Unit, Limoges, France

[16] CHU, Clin Res & Biostat Unit, Dept Med Informat & Evaluat, Limoges, France

[17] Amitie Hosp, Dept Neurol, Bangui, Cent Afr Republ

[18] Univ Montpellier, La Colombiere Hosp, INSERM U1061 Neuropsychiat Epidemiol & Clin Res, Montpellier 5, France

[19] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[20] Golgi Cenci Fdn, Corso San Martino 10, I-20081 Abbiategrasso, Italy

[21] Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, Seongnam, South Korea

[22] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea

[23] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea

[24] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Hlth Aging & Wellness, Kuala Lumpur, Malaysia

[25] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Rehabil Sci & Special Needs, Kuala Lumpur, Malaysia

[26] Univ Sains Malaysia, Sch Hlth Sci, Kota Baharu, Kelantan, Malaysia

[27] Maastricht Univ Med Ctr MUMC, Sch Mental Hlth & Neurosci MHeNs, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[28] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[29] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[30] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[31] Univ New South Wales, Ageing Futures Inst, Sydney, NSW, Australia

[32] Neurosci Res Australia, Sydney, NSW, Australia

[33] Australian Natl Univ, Coll Hlth & Med, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia

[34] Kyushu Univ, Ctr Hlth Sci & Counseling, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan

[35] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[36] Fukuoka Inst Technol, Fac Socioenvironm Studies, Dept Socioenvironm Studies, Higashi Ku, 3-30-1 Wajiro Higashi, Fukuoka 8110295, Japan

[37] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore

[38] Univ New South Wales Sydney, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

[39] Univ New South Wales Sydney, Dementia Collaborat Res Ctr, Sch Psychiat, Sydney, NSW, Australia

[40] Univ New South Wales Sydney, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia

[41] Minist Sci & Innovat, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[42] Univ Zaragoza, Dept Med & Psychiat, Zaragoza, Spain

[43] Inst Invest Sanitaria AragOn, Zaragoza, Spain

[44] Univ Zaragoza, Dept Psychol & Sociol, Zaragoza, Spain

[45] Univ Zaragoza, Dept Microbiol Prevent Med & Publ Hlth, Zaragoza, Spain

来源：

ALZHEIMERS RESEARCH & THERAPY | 2020年 / 12卷 / 01期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Subjective cognitive decline; Prevalence; Epidemiology; Individual participant data; Data harmonization; Cohort study; MINI-MENTAL-STATE; MEMORY COMPLAINTS; DEMENTIA; DETERIORATION; PERFORMANCE; IMPAIRMENT; COMMUNITY; FRAMEWORK; CRITERIA; PEOPLE;

D O I：

10.1186/s13195-020-00734-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

引用

页数：14

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