In vivo efficacy of the CD40 agonist antibody CP-870,893 against a broad range of tumor types: Impact of tumor CD40 expression, dendritic cells, and chemotherapy.

被引：0
|
作者：
Gladue, R. P. [1 ]
Cole, S. H. [1 ]
Donovan, C. [1 ]
Paradis, T. [1 ]
Alpert, R. [1 ]
Natoli, E. [1 ]
Bedian, V. [1 ]
机构：
[1] Pfizer Global Res & Dev, Groton, CT USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2006年 / 24卷 / 18期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：103S / 103S
页数：1
相关论文
共 50 条
  • [31] Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer
    Byrne, Katelyn T.
    Betts, Courtney B.
    Mick, Rosemarie
    Sivagnanam, Shamilene
    Bajor, David L.
    Laheru, Daniel A.
    Chiorean, E. Gabriela
    O'Hara, Mark H.
    Liudahl, Shannon M.
    Newcomb, Craig
    Alanio, Cecile
    Ferreira, Ana P.
    Park, Byung S.
    Ohtani, Takuya
    Huffman, Austin P.
    Vayrynen, Sara A.
    Costa, Andressa Dias
    Kaiser, Judith C.
    Lacroix, Andreanne M.
    Redlinger, Colleen
    Stern, Martin
    Nowak, Jonathan A.
    Wherry, E. John
    Cheever, Martin A.
    Wolpin, Brian M.
    Furth, Emma E.
    Jaffee, Elizabeth M.
    Coussens, Lisa M.
    Vonderheide, Robert H.
    CLINICAL CANCER RESEARCH, 2021, 27 (16) : 4574 - 4586
  • [32] CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
    Beatty, Gregory L.
    Chiorean, Elena G.
    Fishman, Matthew P.
    Saboury, Babak
    Teitelbaum, Ursina R.
    Sun, Weijing
    Huhn, Richard D.
    Song, Wenru
    Li, Dongguang
    Sharp, Leslie L.
    Torigian, Drew A.
    O'Dwyer, Peter J.
    Vonderheide, Robert H.
    SCIENCE, 2011, 331 (6024) : 1612 - 1616
  • [33] Tumor antigen cross presentation and the impact of induction of tumor cell apoptosis in vivo on specific CD8 function and CD40 responses
    William, B
    Robinson, S
    Nowak, A
    Marzo, A
    Himbeck, R
    Stumbles, P
    Frelinger, J
    Heath, W
    Scott, B
    Lake, RA
    FASEB JOURNAL, 2003, 17 (07): : C332 - C332
  • [34] Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells
    Farsaneh Sadeghlar
    Annabelle Vogt
    Raphael U. Mohr
    Robert Mahn
    Katrin van Beekum
    Miroslaw Kornek
    Tobias J. Weismüller
    Vittorio Branchi
    Hanno Matthaei
    Marieta Toma
    I. G. H. Schmidt-Wolf
    Jörg C. Kalff
    Christian P. Strassburg
    Maria A. González-Carmona
    Cancer Immunology, Immunotherapy, 2021, 70 : 1451 - 1464
  • [35] Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells
    Sadeghlar, Farsaneh
    Vogt, Annabelle
    Mohr, Raphael U.
    Mahn, Robert
    van Beekum, Katrin
    Kornek, Miroslaw
    Weismueller, Tobias J.
    Branchi, Vittorio
    Matthaei, Hanno
    Toma, Marieta
    Schmidt-Wolf, I. G. H.
    Kalff, Joerg C.
    Strassburg, Christian P.
    Gonzalez-Carmona, Maria A.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2021, 70 (05) : 1451 - 1464
  • [36] CD40 monoclonal antibody activation of antigen-presenting cells improves therapeutic efficacy of tumor-specific T cells
    Bergstrom, RT
    Silverman, DA
    Chambers, K
    Kim, JA
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2004, 130 (01) : 94 - 103
  • [37] Tumor regression induced by intratumor administration of adenovirus vector expressing CD40 ligand and naive dendritic cells
    Kikuchi, T
    Miyazawa, N
    Moore, MAS
    Crystal, RG
    CANCER RESEARCH, 2000, 60 (22) : 6391 - 6395
  • [38] Activation of Tolerogenic Dendritic Cells in the Tumor Draining Lymph Nodes by CD8+ T Cells Engineered to Express CD40 Ligand
    Higham, Eileen M.
    Wittrup, K. Dane
    Chen, Jianzhu
    JOURNAL OF IMMUNOLOGY, 2010, 184 (07): : 3394 - 3400
  • [39] Efficient tumor specific immunity elicited by CD40 ligation dendritic cells via moderate expression of programmed death 1 ligands
    Gu, T
    Zhu, Y
    Li, M
    Chen, Y
    Li, W
    Ge, Y
    Dai, J
    Zhang, X
    EXPERIMENTAL HEMATOLOGY, 2003, 31 (07) : 88 - 88
  • [40] Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo
    Lumsden, JM
    Williams, JA
    Hodes, RJ
    JOURNAL OF IMMUNOLOGY, 2003, 170 (02): : 781 - 787
12345