Susceptibility of Pseudomonas aeruginosa isolates to ceftazidime is unrelated to the expression of the outer membrane protein OprC

被引：3

作者：

Perez, FJ ^{[1
]}

Navarro, D ^{[1
]}

Gimeno, C ^{[1
]}

GarciadeLomas, J ^{[1
]}

机构：

[1] UNIV HOSP VALENCIA,SCH MED,DEPT MICROBIOL,VALENCIA,SPAIN

来源：

CHEMOTHERAPY | 1997年 / 43卷 / 01期

关键词：

ceftazidime; Pseudomonas aeruginosa; porin OprC; outer membrane protein;

D O I：

10.1159/000239531

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previously, it has been postulated that the porin OprC facilitates the diffusion of ceftazidime through the outer membrane of Pseudomonas aeruginosa. To further investigate this claim, the outer membrane protein (OMP) profiles of 22 ceftazidime-susceptible clinical isolates were analyzed. No correlation was found between MIC values and the level of expression of OprC. Further, OprC was either undetectable or expressed in reduced amounts in 12 isolates. In contrast, OprF and OprE were present in all isolates studied. This study suggests that OprC is dispensable for the permeation of ceftazidime through the outer membrane of P. aeruginosa.

引用

页码：27 / 30

页数：4

共 50 条

[21] Correlation between resistance of Pseudomonas aeruginosa to quaternary ammonium compounds and expression of outer membrane protein OprR
Tabata, A
Nagamune, H
Maeda, T
Murakami, K
Miyake, Y
Kourai, H
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (07) : 2093 - 2099
[22] Insertion mutagenesis and membrane topology model of the Pseudomonas aeruginosa outer membrane protein OprM
Wong, KKY
Hancock, REW
JOURNAL OF BACTERIOLOGY, 2000, 182 (09) : 2402 - 2410
[23] Outer Membrane Protein I of Pseudomonas aeruginosa Is a Target of Cationic Antimicrobial Peptide/Protein
Lin, Yu-Min
Wu, Shih-Jung
Chang, Ting-Wei
Wang, Chiu-Feng
Suen, Ching-Shu
Hwang, Ming-Jing
Chang, Margaret Dah-Tsyr
Chen, Yuan-Tsong
Liao, You-Di
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (12) : 8985 - 8994
[24] Molecular characterization of the outer membrane of Pseudomonas aeruginosa
Lopez, Cesar A.
Zgurskaya, Helen
Gnanakaran, S.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2020, 1862 (03):
[25] Repetitive methylene blue-mediated photoantimicrobial chemotherapy changes the susceptibility and expression of the outer membrane proteins of Pseudomonas aeruginosa
Shih, Min-Hsiu
Huang, Fu-Chin
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2013, 10 (04) : 664 - 671
[26] Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa
Gensberg, K
Smith, AW
Brinkman, FSL
Hancock, REW
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (04) : 607 - 608
[27] The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition
Zavan, Lauren
Fang, Haoyun
Johnston, Ella L.
Whitchurch, Cynthia
Greening, David W.
Hill, Andrew F.
Kaparakis-Liaskos, Maria
PROTEOMICS, 2023, 23 (10)
[28] AN OUTER-MEMBRANE PROTEIN CHARACTERISTIC OF MUCOID STRAINS OF PSEUDOMONAS-AERUGINOSA
GRABERT, E
WINGENDER, J
WINKLER, UK
FEMS MICROBIOLOGY LETTERS, 1990, 68 (1-2) : 83 - 88
[29] Antibiotic stress induces a large amount of outer membrane protein in Pseudomonas aeruginosa
Nakajima, A
Hoshikawa, M
Nakae, T
FEMS MICROBIOLOGY LETTERS, 1998, 165 (02) : 261 - 265
[30] Transport of Small Amino Acids by the Outer Membrane Protein OPRG of Pseudomonas Aeruginosa
Seelheim, Patrick
Gari, Raghavendar Reddy Sanganna
Kucharska, Iga
Tamm, Lukas K.
BIOPHYSICAL JOURNAL, 2017, 112 (03) : 417A - 417A

← 1 2 3 4 5 →